TUFM Antibody (PACO23430)
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주문- SKU:
- PACO23430
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TUFM Antibody (PACO23430) |
Antibody SKU: | PACO23430 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthesized peptide derived from internal of human TUFM. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot analysis of extracts from LOVO cells and 3T3 cells, using TUFM antiobdy. |
![]() | Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using TUFM antibody. |
Background: | This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. |
Synonyms: | Elongation factor Tu; mitochondrial; EF-Tu; P43; |
UniProt Protein Function: | EFTU: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Defects in TUFM are the cause of combined oxidative phosphorylation deficiency type 4 (COXPD4). COXPD4 is characterized by neonatal lactic acidosis, rapidly progressive encephalopathy, severely decreased mitochondrial protein synthesis, and combined deficiency of mtDNA-related mitochondrial respiratory chain complexes. Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily. |
UniProt Protein Details: | Protein type:Translation elongation; RNA-binding; Translation; Mitochondrial Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: membrane; mitochondrion Molecular Function:GTP binding; GTPase activity; protein binding; translation elongation factor activity Biological Process: mitochondrial translation; organelle organization and biogenesis; translational elongation Disease: Combined Oxidative Phosphorylation Deficiency 4 |
NCBI Summary: | This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy. A pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2008] |
UniProt Code: | P49411 |
NCBI GenInfo Identifier: | 1706611 |
NCBI Gene ID: | 7284 |
NCBI Accession: | P49411.2 |
UniProt Secondary Accession: | P49411,O15276, |
UniProt Related Accession: | P49411 |
Molecular Weight: | |
NCBI Full Name: | Elongation factor Tu, mitochondrial |
NCBI Synonym Full Names: | Tu translation elongation factor, mitochondrial |
NCBI Official Symbol: | TUFM |
NCBI Official Synonym Symbols: | P43; EFTU; COXPD4; EF-TuMT |
NCBI Protein Information: | elongation factor Tu, mitochondrial |
UniProt Protein Name: | Elongation factor Tu, mitochondrial |
UniProt Synonym Protein Names: | P43 |
UniProt Gene Name: | TUFM |
UniProt Entry Name: | EFTU_HUMAN |