UniProt Protein Function: | TRPV5: Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)- dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV5 sub-subfamily. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Motility/polarity/chemotaxis; Channel, cation Chromosomal Location of Human Ortholog: 7q35 Cellular Component: integral to plasma membrane; apical plasma membrane; plasma membrane Molecular Function:calmodulin binding; protein binding; calcium channel activity Biological Process: calcium ion transport; transmembrane transport; protein tetramerization |
NCBI Summary: | This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NQA5 |
NCBI GenInfo Identifier: | 62901471 |
NCBI Gene ID: | 56302 |
NCBI Accession: | Q9NQA5.2 |
UniProt Secondary Accession: | Q9NQA5,Q8N4C1, Q8NDW5, Q8NDX7, Q8NDX8, Q96PM6, A4D2H7 E9PBZ6, |
UniProt Related Accession: | Q9NQA5 |
Molecular Weight: | 729 |
NCBI Full Name: | Transient receptor potential cation channel subfamily V member 5 |
NCBI Synonym Full Names: | transient receptor potential cation channel, subfamily V, member 5 |
NCBI Official Symbol: | TRPV5 |
NCBI Official Synonym Symbols: | CAT2; ECAC1; OTRPC3 |
NCBI Protein Information: | transient receptor potential cation channel subfamily V member 5; calcium transporter 2; osm-9-like TRP channel 3; calcium transport protein 2; epithelial calcium channel 1 |
UniProt Protein Name: | Transient receptor potential cation channel subfamily V member 5 |
UniProt Synonym Protein Names: | Calcium transport protein 2; CaT2; Epithelial calcium channel 1; ECaC; ECaC1; Osm-9-like TRP channel 3; OTRPC3 |
Protein Family: | Transient receptor potential cation channel subfamily |
UniProt Gene Name: | TRPV5 |
UniProt Entry Name: | TRPV5_HUMAN |