UniProt Protein Function: | TRPC5: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily. |
UniProt Protein Details: | Protein type:Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: Xq23 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:calcium channel activity; protein binding; store-operated calcium channel activity Biological Process: calcium ion transport; cytosolic calcium ion homeostasis; manganese ion transport; nervous system development |
NCBI Summary: | This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010] |
UniProt Code: | Q9UL62 |
NCBI GenInfo Identifier: | 10720321 |
NCBI Gene ID: | 7224 |
NCBI Accession: | Q9UL62.1 |
UniProt Secondary Accession: | Q9UL62,O75233, Q5JXY8, Q9Y514, B2RP53, |
UniProt Related Accession: | Q9UL62 |
Molecular Weight: | 111,412 Da |
NCBI Full Name: | Short transient receptor potential channel 5 |
NCBI Synonym Full Names: | transient receptor potential cation channel subfamily C member 5 |
NCBI Official Symbol: | TRPC5 |
NCBI Official Synonym Symbols: | TRP5; PPP1R159 |
NCBI Protein Information: | short transient receptor potential channel 5 |
UniProt Protein Name: | Short transient receptor potential channel 5 |
UniProt Synonym Protein Names: | Transient receptor protein 5; TRP-5; hTRP-5; hTRP5 |
Protein Family: | Short transient receptor potential channel |
UniProt Gene Name: | TRPC5 |
UniProt Entry Name: | TRPC5_HUMAN |