TRNT1 Antibody (PACO59281)
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주문- SKU:
- PACO59281
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TRNT1 Antibody (PACO59281) |
Antibody SKU: | PACO59281 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human CCA tRNA nucleotidyltransferase 1, mitochondrial protein (128-293AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: 293T whole cell lysate, HepG2 whole cell lysate. All lanes: TRNT1 antibody at 5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 51, 48, 7 kDa. Observed band size: 51, 48 kDa. |
Background: | Isoform 1: Adds and repairs the conserved 3'-CCA sequence necessary for the attachment of amino acid, to the 3' terminus of tRNA molecules, using CTP and ATP as substrates. |
Synonyms: | CCA tRNA nucleotidyltransferase 1, mitochondrial (EC 2.7.7.72) (Mitochondrial tRNA nucleotidyl transferase, CCA-adding) (mt CCA-adding enzyme) (mt tRNA CCA-diphosphorylase) (mt tRNA CCA-pyrophosphorylase) (mt tRNA adenylyltransferase), TRNT1 |
UniProt Protein Function: | TRNT1: Isoform 1: Adds and repairs the conserved 3'-CCA sequence necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 2.7.7.72; RNA processing; Mitochondrial; Transferase Chromosomal Location of Human Ortholog: 3p25.1 Cellular Component: intracellular; mitochondrial matrix; mitochondrion; nucleoplasm Molecular Function:ATP binding; RNA polymerase activity; tRNA adenylyltransferase activity; tRNA binding Biological Process: protein targeting to mitochondrion; tRNA 3'-end processing; tRNA 3'-terminal CCA addition Disease: Retinitis Pigmentosa And Erythrocytic Microcytosis; Sideroblastic Anemia With B-cell Immunodeficiency, Periodic Fevers, And Developmental Delay |
NCBI Summary: | The protein encoded by this gene is a CCA-adding enzyme which belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. This essential enzyme functions by catalyzing the addition of the conserved nucleotide triplet CCA to the 3' terminus of tRNA molecules. Mutations in this gene result in sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
UniProt Code: | Q96Q11 |
NCBI GenInfo Identifier: | 15214804 |
NCBI Gene ID: | 51095 |
NCBI Accession: | BC012537 |
UniProt Secondary Accession: | Q96Q11,Q8ND57, Q9BS97, Q9Y362, A8K2Z6, B7WP13, C9JKA2 |
UniProt Related Accession: | Q96Q11 |
Molecular Weight: | 6,937 Da |
NCBI Full Name: | Homo sapiens tRNA nucleotidyl transferase, CCA-adding, 1, mRNA |
NCBI Synonym Full Names: | tRNA nucleotidyl transferase 1 |
NCBI Official Symbol: | TRNT1 |
NCBI Official Synonym Symbols: | CCA1; RPEM; SIFD; MtCCA; CGI-47 |
NCBI Protein Information: | CCA tRNA nucleotidyltransferase 1, mitochondrial |
UniProt Protein Name: | CCA tRNA nucleotidyltransferase 1, mitochondrial |
UniProt Synonym Protein Names: | Mitochondrial tRNA nucleotidyl transferase, CCA-adding; mt CCA-adding enzyme; mt tRNA CCA-diphosphorylase; mt tRNA CCA-pyrophosphorylase; mt tRNA adenylyltransferase |
Protein Family: | CCA tRNA nucleotidyltransferase |
UniProt Gene Name: | TRNT1 |
UniProt Entry Name: | TRNT1_HUMAN |
Antibodies |
Anti-TRNT1 Antibody (CAB17699) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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