UniProt Protein Function: | TRAF7: E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. Belongs to the WD repeat TRAF7 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system; EC 6.3.2.-; Ubiquitin ligase; EC 6.3.2.19; Ligase Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: intracellular membrane-bound organelle; perinuclear region of cytoplasm; cytoplasmic membrane-bound vesicle; plasma membrane; nucleus; cytosol; ubiquitin ligase complex Molecular Function:protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity Biological Process: positive regulation of protein sumoylation; regulation of protein localization; positive regulation of MAPKKK cascade; transcription, DNA-dependent; apoptosis; activation of MAPKKK activity; protein ubiquitination; negative regulation of transcription from RNA polymerase II promoter |
NCBI Summary: | Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004] |
UniProt Code: | Q6Q0C0 |
NCBI GenInfo Identifier: | 54036486 |
NCBI Gene ID: | 84231 |
NCBI Accession: | Q6Q0C0.1 |
UniProt Secondary Accession: | Q6Q0C0,Q9H073, |
UniProt Related Accession: | Q6Q0C0 |
Molecular Weight: | 670 |
NCBI Full Name: | E3 ubiquitin-protein ligase TRAF7 |
NCBI Synonym Full Names: | TNF receptor-associated factor 7, E3 ubiquitin protein ligase |
NCBI Official Symbol: | TRAF7 |
NCBI Official Synonym Symbols: | RFWD1; RNF119 |
NCBI Protein Information: | E3 ubiquitin-protein ligase TRAF7; RING finger protein 119; ring finger and WD repeat domain 1; RING finger and WD repeat-containing protein 1 |
UniProt Protein Name: | E3 ubiquitin-protein ligase TRAF7 |
UniProt Synonym Protein Names: | RING finger and WD repeat-containing protein 1; RING finger protein 119; TNF receptor-associated factor 7 |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | TRAF7 |
UniProt Entry Name: | TRAF7_HUMAN |