UniProt Protein Function: | TRADD: Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. Heterodimer with TNFRSF1A/TNFR1. Interacts with DAB2IP, FADD, HIPK2, KRT14, KRT16, KRT17, KRT18, RIPK1, SQSTM1, TRAF1, TRAF2 and TRPC4AP. Found in all examined tissues. |
UniProt Protein Details: | Protein type:Apoptosis; Adaptor/scaffold Chromosomal Location of Human Ortholog: 16q22 Cellular Component: cytoskeleton; cytoplasm; nucleus; cytosol; receptor complex; lipid raft Molecular Function:identical protein binding; protein binding; signal transducer activity; protein complex binding; kinase binding; tumor necrosis factor receptor binding; molecular adaptor activity Biological Process: positive regulation of hair follicle development; caspase activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; tumor necrosis factor-mediated signaling pathway; induction of apoptosis via death domain receptors; apoptosis; protein heterooligomerization; positive regulation of apoptosis; signal transduction; activation of NF-kappaB transcription factor |
NCBI Summary: | The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q15628 |
NCBI GenInfo Identifier: | 6094511 |
NCBI Gene ID: | 8717 |
NCBI Accession: | Q15628.2 |
UniProt Secondary Accession: | Q15628,Q52NZ1, B2RDS3, B3KQZ9, |
UniProt Related Accession: | Q15628 |
Molecular Weight: | 312 |
NCBI Full Name: | Tumor necrosis factor receptor type 1-associated DEATH domain protein |
NCBI Synonym Full Names: | TNFRSF1A-associated via death domain |
NCBI Official Symbol: | TRADD |
NCBI Official Synonym Symbols: | Hs.89862 |
NCBI Protein Information: | tumor necrosis factor receptor type 1-associated DEATH domain protein; TNFR1-associated death domain protein; tumor necrosis factor receptor-1-associated protein; tumor necrosis factor receptor type 1 associated death domain protein |
UniProt Protein Name: | Tumor necrosis factor receptor type 1-associated DEATH domain protein |
UniProt Synonym Protein Names: | TNFRSF1A-associated via death domain |
Protein Family: | Tumor necrosis factor receptor type 1-associated DEATH domain protein |
UniProt Gene Name: | TRADD |
UniProt Entry Name: | TRADD_HUMAN |