TNFAIP8 Antibody (PACO44552)
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주문- SKU:
- PACO44552
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TNFAIP8 Antibody (PACO44552) |
Antibody SKU: | PACO44552 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Tumor necrosis factor alpha-induced protein 8 protein (1-198AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: TNFAIP8 antibody at 2.32µg/ml. Lane 1: A431 whole cell lysate. Lane 2: PC-3 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 24, 23, 22, 25 kDa. Observed band size: 22 kDa.. |
![]() | Immunohistochemistry of paraffin-embedded human breast cancer using PACO44552 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human colon cancer using PACO44552 at dilution of 1:100. |
Background: | Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. |
Synonyms: | Tumor necrosis factor alpha-induced protein 8 (TNF alpha-induced protein 8) (Head and neck tumor and metastasis-related protein) (MDC-3.13) (NF-kappa-B-inducible DED-containing protein) (NDED) (SCC-S2) (TNF-induced protein GG2-1), TNFAIP8 |
UniProt Protein Function: | TNFAIP8: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. Belongs to the TNFAIP8 family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 5q23.1 Cellular Component: cytoplasm Molecular Function:caspase inhibitor activity Biological Process: defense response to Gram-positive bacterium; interleukin-1 beta production; negative regulation of caspase activity; negative regulation of apoptosis |
UniProt Code: | O95379 |
NCBI GenInfo Identifier: | 74735587 |
NCBI Gene ID: | 25816 |
NCBI Accession: | O95379.1 |
UniProt Secondary Accession: | O95379,Q9P1Q1, Q9UER5, Q9UP47, B3KMH1, B3KMI2, B7Z713 |
UniProt Related Accession: | O95379 |
Molecular Weight: | 24,385 Da |
NCBI Full Name: | Tumor necrosis factor alpha-induced protein 8 |
NCBI Synonym Full Names: | tumor necrosis factor, alpha-induced protein 8 |
NCBI Official Symbol: | TNFAIP8 |
NCBI Official Synonym Symbols: | NDED; GG2-1; SCCS2; SCC-S2; MDC-3.13 |
NCBI Protein Information: | tumor necrosis factor alpha-induced protein 8; TNF-induced protein GG2-1; TNF alpha-induced protein 8; NF-kappa-B-inducible DED-containing protein; head and neck tumor and metastasis-related protein |
UniProt Protein Name: | Tumor necrosis factor alpha-induced protein 8 |
UniProt Synonym Protein Names: | Head and neck tumor and metastasis-related protein; MDC-3.13; NF-kappa-B-inducible DED-containing protein; NDED; SCC-S2; TNF-induced protein GG2-1 |
Protein Family: | Tumor necrosis factor alpha-induced protein |
UniProt Gene Name: | TNFAIP8 |
UniProt Entry Name: | TFIP8_HUMAN |