TMPRSS2 Antibody (PACO16897)
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주문- SKU:
- PACO16897
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TMPRSS2 Antibody (PACO16897) |
Antibody SKU: | PACO16897 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human TMPRSS2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: PACO16897(TMPRSS2 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes. |
Background: | This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. |
Synonyms: | transmembrane protease, serine 2 |
UniProt Protein Function: | TMPRSS2: a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] |
UniProt Protein Details: | Protein type:EC 3.4.21.-; Protease; Membrane protein, integral Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:protein binding; serine-type peptidase activity Biological Process: positive regulation of virion penetration into host cell; protein autoprocessing; proteolysis |
NCBI Summary: | This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] |
UniProt Code: | O15393 |
NCBI GenInfo Identifier: | 115502469 |
NCBI Gene ID: | 7113 |
NCBI Accession: | O15393.3 |
UniProt Secondary Accession: | O15393,Q6GTK7, Q9BXX1, A8K6Z8, B2R8E5, B7Z459, D3DSJ2 F8WES1, |
UniProt Related Accession: | O15393 |
Molecular Weight: | 57,690 Da |
NCBI Full Name: | Transmembrane protease serine 2 |
NCBI Synonym Full Names: | transmembrane protease, serine 2 |
NCBI Official Symbol: | TMPRSS2 |
NCBI Official Synonym Symbols: | PP9284; PRSS10 |
NCBI Protein Information: | transmembrane protease serine 2 |
UniProt Protein Name: | Transmembrane protease serine 2 |
UniProt Synonym Protein Names: | Serine protease 10 |
Protein Family: | Transmembrane protease serine |
UniProt Gene Name: | TMPRSS2 |
UniProt Entry Name: | TMPS2_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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