TIMP3 Antibody (PACO56282)
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주문- SKU:
- PACO56282
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TIMP3 Antibody (PACO56282) |
Antibody SKU: | PACO56282 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Metalloproteinase inhibitor 3 protein (1-184AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | IHC image of PACO56282 diluted at 1:200 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
Background: | Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. |
Synonyms: | Metalloproteinase inhibitor 3 (Protein MIG-5) (Tissue inhibitor of metalloproteinases 3) (TIMP-3), TIMP3 |
UniProt Protein Function: | TIMP3: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. Interacts with EFEMP1. Belongs to the protease inhibitor I35 (TIMP) family. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 22q12.3 Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; basement membrane; nucleus Molecular Function:metalloendopeptidase inhibitor activity; protein binding; protease binding; metal ion binding Biological Process: negative regulation of metalloenzyme activity; visual perception; response to cytokine stimulus; response to hormone stimulus; negative regulation of membrane protein ectodomain proteolysis Disease: Fundus Dystrophy, Pseudoinflammatory, Of Sorsby |
NCBI Summary: | This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008] |
UniProt Code: | P35625 |
NCBI GenInfo Identifier: | 730948 |
NCBI Gene ID: | 7078 |
NCBI Accession: | P35625.2 |
UniProt Secondary Accession: | P35625,Q5THV4, Q9UC74, Q9UGS2, B2RBY9, |
UniProt Related Accession: | P35625 |
Molecular Weight: | 24,145 Da |
NCBI Full Name: | Metalloproteinase inhibitor 3 |
NCBI Synonym Full Names: | TIMP metallopeptidase inhibitor 3 |
NCBI Official Symbol: | TIMP3 |
NCBI Official Synonym Symbols: | SFD; K222; K222TA2; HSMRK222 |
NCBI Protein Information: | metalloproteinase inhibitor 3; TIMP-3; MIG-5 protein; protein MIG-5; tissue inhibitor of metalloproteinases 3 |
UniProt Protein Name: | Metalloproteinase inhibitor 3 |
UniProt Synonym Protein Names: | Protein MIG-5; Tissue inhibitor of metalloproteinases 3; TIMP-3 |
Protein Family: | Metalloproteinase inhibitor |
UniProt Gene Name: | TIMP3 |
UniProt Entry Name: | TIMP3_HUMAN |
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