TIAM1 Antibody (PACO46494)
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주문- SKU:
- PACO46494
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | TIAM1 Antibody (PACO46494) |
Antibody SKU: | PACO46494 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human T-lymphoma invasion and metastasis-inducing protein 1 protein (52-224AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human spleen tissue using PACO46494 at dilution of 1:100. | |
Immunofluorescent analysis of HepG2 cells using PACO46494 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration. |
Synonyms: | T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1), TIAM1 |
UniProt Protein Function: | TIAM1: modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Regulates migration, cell-matrix and cell-cell adhesion by modulating the actin cytoskeleton through the GTPase, Rac1. Binding to Rac1 and the Arp2/3 complex may drive actin polymerization at specific sites, thus inducing dynamic morphological changes. |
UniProt Protein Details: | Protein type:GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Chromosomal Location of Human Ortholog: 21q22.11 Cellular Component: cytosol; extrinsic to internal side of plasma membrane; intercellular junction; plasma membrane Molecular Function:guanyl-nucleotide exchange factor activity; kinase binding; protein binding; Rac guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity Biological Process: cell migration; cell-matrix adhesion; ephrin receptor signaling pathway; positive regulation of apoptosis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of protein binding; Rac protein signal transduction; regulation of small GTPase mediated signal transduction |
UniProt Code: | Q13009 |
NCBI GenInfo Identifier: | 152031709 |
NCBI Gene ID: | 7074 |
NCBI Accession: | Q13009.2 |
UniProt Secondary Accession: | Q13009,Q17RT7, B7ZLR6, F5GZ53, |
UniProt Related Accession: | Q13009 |
Molecular Weight: | 178kDa |
NCBI Full Name: | T-lymphoma invasion and metastasis-inducing protein 1 |
NCBI Synonym Full Names: | T-cell lymphoma invasion and metastasis 1 |
NCBI Official Symbol: | TIAM1 |
NCBI Protein Information: | T-lymphoma invasion and metastasis-inducing protein 1 |
UniProt Protein Name: | T-lymphoma invasion and metastasis-inducing protein 1 |
Protein Family: | T-lymphoma invasion and metastasis-inducing protein |
UniProt Gene Name: | TIAM1 |
Antibodies |
Anti-TIAM1 Antibody (CAB10252) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |