THOC6 Antibody (PACO63435)
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주문- SKU:
- PACO63435
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | THOC6 Antibody (PACO63435) |
Antibody SKU: | PACO63435 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human THO complex subunit 6 homolog protein (56-315AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: K562 whole cell lysate, SH-SY5Y whole cell lysate. All lanes: THOC6 antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 38, 35, 33 kDa. Observed band size: 35 kDa. |
Background: | Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development. |
Synonyms: | THO complex subunit 6 homolog (Functional spliceosome-associated protein 35) (fSAP35) (WD repeat-containing protein 58), THOC6, WDR58 |
UniProt Protein Function: | THOC6: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4. Belongs to the WD repeat THOC6 family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:RNA splicing; Spliceosome Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: nuclear chromosome, telomeric region; nucleoplasm; nucleus Biological Process: central nervous system development; intronless viral mRNA export from host nucleus; mRNA 3'-end processing; mRNA export from nucleus; negative regulation of apoptosis; RNA export from nucleus; termination of RNA polymerase II transcription Disease: Beaulieu-boycott-innes Syndrome |
UniProt Code: | Q86W42 |
NCBI GenInfo Identifier: | 74759455 |
NCBI Gene ID: | 79228 |
NCBI Accession: | Q86W42.1 |
UniProt Secondary Accession: | Q86W42,Q8NBR1, Q9BTV9, B2RA85, |
UniProt Related Accession: | Q86W42 |
Molecular Weight: | 32,891 Da |
NCBI Full Name: | THO complex subunit 6 homolog |
NCBI Synonym Full Names: | THO complex 6 |
NCBI Official Symbol: | THOC6 |
NCBI Official Synonym Symbols: | BBIS; WDR58; fSAP35 |
NCBI Protein Information: | THO complex subunit 6 homolog |
UniProt Protein Name: | THO complex subunit 6 homolog |
UniProt Synonym Protein Names: | Functional spliceosome-associated protein 35; fSAP35; WD repeat-containing protein 58 |
Protein Family: | THO complex |
UniProt Gene Name: | THOC6 |
UniProt Entry Name: | THOC6_HUMAN |