TFB2M Antibody (PACO51038)
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주문- SKU:
- PACO51038
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TFB2M Antibody (PACO51038) |
Antibody SKU: | PACO51038 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Dimethyladenosine transferase 2, mitochondrial protein (30-108AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO51038 at dilution of 1:100. |
Background: | S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity. |
Synonyms: | Dimethyladenosine transferase 2, mitochondrial (EC 2.1.1) (Hepatitis C virus NS5A-transactivated protein 5) (HCV NS5A-transactivated protein 5) (Mitochondrial 12S rRNA dimethylase 2) (Mitochondrial transcription factor B2) (h-mtTFB) (h-mtTFB2) (hTFB2M) (mtTFB2) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2), TFB2M, NS5ATP5 |
UniProt Protein Function: | TFB2M: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity. Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily. |
UniProt Protein Details: | Protein type:EC 2.1.1.-; Methyltransferase; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 1q44 Cellular Component: mitochondrial matrix Molecular Function:rRNA (adenine-N6,N6-)-dimethyltransferase activity; transcription cofactor activity Biological Process: mitochondrion organization and biogenesis; positive regulation of transcription, DNA-dependent; organelle organization and biogenesis; rRNA methylation; gene expression; transcription from mitochondrial promoter; transcription initiation from mitochondrial promoter |
UniProt Code: | Q9H5Q4 |
NCBI GenInfo Identifier: | 11641289 |
NCBI Gene ID: | 64216 |
NCBI Accession: | NP_071761.1 |
UniProt Related Accession: | Q9H5Q4 |
Molecular Weight: | 45kDa |
NCBI Full Name: | dimethyladenosine transferase 2, mitochondrial |
NCBI Synonym Full Names: | transcription factor B2, mitochondrial |
NCBI Official Symbol: | TFB2M |
NCBI Official Synonym Symbols: | Hkp1; mtTFB2 |
NCBI Protein Information: | dimethyladenosine transferase 2, mitochondrial |
UniProt Protein Name: | Dimethyladenosine transferase 2, mitochondrial |
UniProt Synonym Protein Names: | Hepatitis C virus NS5A-transactivated protein 5; HCV NS5A-transactivated protein 5; Mitochondrial 12S rRNA dimethylase 2; Mitochondrial transcription factor B2; h-mtTFB; h-mtTFB2; hTFB2M; mtTFB2; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2 |
Protein Family: | Dimethyladenosine transferase |
UniProt Gene Name: | TFB2M |
UniProt Entry Name: | TFB2M_HUMAN |
Antibodies |
Anti-TFB2M Antibody (CAB14921) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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