TCTN2 Antibody (PACO43763)
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주문- SKU:
- PACO43763
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TCTN2 Antibody (PACO43763) |
Antibody SKU: | PACO43763 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Tectonic-2 protein (420-670AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: TCTN2 antibody at 10µg/ml. Lane 1: Jurkat whole cell lysate. Lane 2: A549 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 77 kDa. Observed band size: 77 kDa. |
![]() | Immunohistochemistry of paraffin-embedded human liver tissue using PACO43763 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human skin tissue using PACO43763 at dilution of 1:100. |
Background: | Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction (By similarity). |
Synonyms: | Tectonic-2, TCTN2, C12orf38 TECT2 |
UniProt Protein Function: | TCTN2: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction. Defects in TCTN2 are the cause of Meckel syndrome type 8 (MKS8). A disorder characterized by a combination of renal cysts and variably associated features including developmental anomalies of the central nervous system (typically encephalocele), hepatic ductal dysplasia and cysts, and polydactyly. Defects in TCTN2 may be a cause of Joubert syndrome, a disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy and renal disease. Belongs to the tectonic family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: cytoskeleton; cytoplasm; integral to membrane Biological Process: smoothened signaling pathway; organelle organization and biogenesis; cilium biogenesis Disease: Joubert Syndrome 1; Meckel Syndrome, Type 8 |
NCBI Summary: | This gene encodes a type I membrane protein that belongs to the tectonic family. Studies in mice suggest that this protein may be involved in hedgehog signaling, and essential for ciliogenesis. Mutations in this gene are associated with Meckel syndrome type 8. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
UniProt Code: | Q96GX1 |
NCBI GenInfo Identifier: | 219803496 |
NCBI Gene ID: | 79867 |
NCBI Accession: | |
UniProt Related Accession: | Q96GX1 |
Molecular Weight: | |
NCBI Full Name: | tectonic-2 isoform 2 |
NCBI Synonym Full Names: | tectonic family member 2 |
NCBI Official Symbol: | TCTN2 |
NCBI Official Synonym Symbols: | MKS8; TECT2; JBTS24; C12orf38 |
NCBI Protein Information: | tectonic-2 |
UniProt Protein Name: | Tectonic-2 |
Protein Family: | Tectonic |
UniProt Gene Name: | TCTN2 |
UniProt Entry Name: | TECT2_HUMAN |