TCAP Antibody (PACO44307)
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주문- SKU:
- PACO44307
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | TCAP Antibody (PACO44307) |
Antibody SKU: | PACO44307 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Telethonin protein (1-167AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO44307 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human heart tissue using PACO44307 at dilution of 1:100. |
Background: | Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk. |
Synonyms: | Telethonin (Titin cap protein), TCAP |
UniProt Protein Function: | Telethonin: a muscle assembly regulating factor that interacts with the giant kinase titin. Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. Telethonin is found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 17q12 Cellular Component: I band; cytosol; Z disc Molecular Function:protein binding, bridging; protein binding; structural constituent of muscle; titin binding; FATZ binding Biological Process: adult heart development; skeletal muscle contraction; cardiac muscle hypertrophy; somitogenesis; muscle thin filament assembly; detection of mechanical stimulus; cardiac myofibril assembly; sarcomere organization; muscle filament sliding; muscle thick filament assembly; cardiac muscle fiber development; cardiac muscle morphogensis; sarcomerogenesis; protein complex assembly; otic vesicle formation; cardiac muscle contraction Disease: Muscular Dystrophy, Limb-girdle, Type 2g; Cardiomyopathy, Dilated, 1n |
NCBI Summary: | Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. [provided by RefSeq, Jul 2008] |
UniProt Code: | O15273 |
NCBI GenInfo Identifier: | 3024716 |
NCBI Gene ID: | 8557 |
NCBI Accession: | O15273.1 |
UniProt Secondary Accession: | O15273,Q96L27, |
UniProt Related Accession: | O15273 |
Molecular Weight: | Observed MW: 19kDaCalculated MW: 19kDa |
NCBI Full Name: | Telethonin |
NCBI Synonym Full Names: | titin-cap |
NCBI Official Symbol: | TCAP |
NCBI Official Synonym Symbols: | TELE; CMD1N; T-cap; LGMD2G; telethonin |
NCBI Protein Information: | telethonin; titin cap protein; 19 kDa sarcomeric protein; limb girdle muscular dystrophy 2G (autosomal recessive) |
UniProt Protein Name: | Telethonin |
UniProt Synonym Protein Names: | Titin cap protein |
Protein Family: | Telethonin |
UniProt Gene Name: | TCAP |
UniProt Entry Name: | TELT_HUMAN |