TBCE Antibody (PACO44852)
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주문- SKU:
- PACO44852
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TBCE Antibody (PACO44852) |
Antibody SKU: | PACO44852 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Tubulin-specific chaperone E protein (328-527AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human prostate cancer using PACO44852 at dilution of 1:100. |
Background: | Tubulin-folding protein; involved in the second step of the tubulin folding pathway. Seems to be implicated in the maintenance of the neuronal microtubule network. Involved in regulation of tubulin heterodimer dissociation. |
Synonyms: | Tubulin-specific chaperone E (Tubulin-folding cofactor E), TBCE |
UniProt Protein Function: | TBCE: Tubulin-folding protein; involved in the second step of the tubulin folding pathway. Seems to be implicated in the maintenance of the neuronal microtubule network. Involved in regulation of tubulin heterodimer dissociation. Defects in TBCE are a cause of hypoparathyroidism- retardation-dysmorphism syndrome (HRD); also known as hypoparathyroidism with short stature, mental retardation, and seizures or Sanjad-Sakati syndrome. HRD is an autosomal recessive disorder reported almost exclusively in Middle Eastern populations. Defects in TBCE are the cause of Kenny-Caffey syndrome type 1 (KCS1). KCS1 is similar to HRD with the additional features of osteosclerosis and recurrent bacterial infections. Belongs to the TBCE family. |
UniProt Protein Details: | Protein type:Chaperone Chromosomal Location of Human Ortholog: 1q42.3 Cellular Component: microtubule; cytoplasm Molecular Function:chaperone binding Biological Process: 'de novo' posttranslational protein folding; developmental growth; cellular protein metabolic process; protein folding; adult locomotory behavior; muscle atrophy; microtubule cytoskeleton organization and biogenesis; peripheral nervous system neuron axonogenesis; post-chaperonin tubulin folding pathway; post-embryonic development Disease: Hypoparathyroidism-retardation-dysmorphism Syndrome; Kenny-caffey Syndrome, Type 1 |
NCBI Summary: | Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q15813 |
NCBI GenInfo Identifier: | 74762146 |
NCBI Gene ID: | 6905 |
NCBI Accession: | Q15813.1 |
UniProt Secondary Accession: | Q15813,A8K8C2, B7Z3P1, |
UniProt Related Accession: | Q15813 |
Molecular Weight: | 527 |
NCBI Full Name: | Tubulin-specific chaperone E |
NCBI Synonym Full Names: | tubulin folding cofactor E |
NCBI Official Symbol: | TBCE |
NCBI Official Synonym Symbols: | HRD; KCS; KCS1; pac2 |
NCBI Protein Information: | tubulin-specific chaperone E; hypoparathyroidism, growth and mental retardation, and dysmorphism |
UniProt Protein Name: | Tubulin-specific chaperone E |
UniProt Synonym Protein Names: | Tubulin-folding cofactor E |
Protein Family: | Tubulin-specific chaperone |
UniProt Gene Name: | TBCE |
UniProt Entry Name: | TBCE_HUMAN |