TAF1C Antibody (PACO43926)
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주문- SKU:
- PACO43926
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TAF1C Antibody (PACO43926) |
Antibody SKU: | PACO43926 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human TATA box-binding protein-associated factor RNA polymerase I subunit C protein (70-320AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO43926 at dilution of 1:100. | |
Immunofluorescent analysis of MCF-7 cells using PACO43926 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO43926 at dilution of 1:100. |
Background: | Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3. |
Synonyms: | TATA box-binding protein-associated factor RNA polymerase I subunit C (RNA polymerase I-specific TBP-associated factor 110 kDa) (TAFI110) (TATA box-binding protein-associated factor 1C) (TBP-associated factor 1C) (Transcription initiation factor SL1/TIF-IB subunit C), TAF1C |
UniProt Protein Function: | TAF1C: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription initiation complex Chromosomal Location of Human Ortholog: 16q24 Cellular Component: nucleoplasm Molecular Function:protein binding; DNA binding Biological Process: chromatin silencing at rDNA; transcription from RNA polymerase II promoter; negative regulation of gene expression, epigenetic; RNA elongation from RNA polymerase I promoter; transcription from RNA polymerase I promoter; gene expression; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoter; regulation of gene expression, epigenetic |
NCBI Summary: | Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011] |
UniProt Code: | Q15572 |
NCBI GenInfo Identifier: | 313104019 |
NCBI Gene ID: | 9013 |
NCBI Accession: | Q15572.2 |
UniProt Secondary Accession: | Q15572,Q59F67, Q8N6V3, B7Z5K5, B7Z5S4, B7Z908, B7Z9L7 |
UniProt Related Accession: | Q15572 |
Molecular Weight: | 869 |
NCBI Full Name: | TATA box-binding protein-associated factor RNA polymerase I subunit C |
NCBI Synonym Full Names: | TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa |
NCBI Official Symbol: | TAF1C |
NCBI Official Synonym Symbols: | SL1; TAFI95; TAFI110; MGC:39976 |
NCBI Protein Information: | TATA box-binding protein-associated factor RNA polymerase I subunit C; SL1, 110kD subunit; TBP-associated factor 1C; transcription factor SL1; TATA box-binding protein-associated factor 1C; transcription initiation factor SL1/TIF-IB subunit C; RNA polymerase I-specific TBP-associated factor 110 kDa; TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kD |
UniProt Protein Name: | TATA box-binding protein-associated factor RNA polymerase I subunit C |
UniProt Synonym Protein Names: | RNA polymerase I-specific TBP-associated factor 110 kDa; TAFI110; TATA box-binding protein-associated factor 1C; TBP-associated factor 1C; Transcription initiation factor SL1/TIF-IB subunit C |
Protein Family: | TATA box-binding protein-associated factor |
UniProt Gene Name: | TAF1C |
UniProt Entry Name: | TAF1C_HUMAN |