TAF1B Antibody (PACO43762)
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주문- SKU:
- PACO43762
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TAF1B Antibody (PACO43762) |
Antibody SKU: | PACO43762 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:200-1:1000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human TATA box-binding protein-associated factor RNA polymerase I subunit B protein (369-588AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot All lanes: TATA box-binding protein-associated factor RNA polymerase I subunit B antibody at 4µg/ml + Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 69, 61, 40 kDa Observed band size: 69 kDa |
![]() | Immunohistochemistry of paraffin-embedded human colon cancer using PACO43762 at dilution of 1:100 |
Background: | Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during trancription initiation such as preinitiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3. |
Synonyms: | TATA box-binding protein-associated factor RNA polymerase I subunit B (RNA polymerase I-specific TBP-associated factor 63 kDa) (TAFI63) (TATA box-binding protein-associated factor 1B) (TBP-associated factor 1B) (Transcription initiation factor SL1/TIF-IB subunit B), TAF1B |
UniProt Protein Function: | TAF1B: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during trancription initiation such as preinitiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3. Belongs to the RRN7/TAF1B family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nucleolus; DNA-binding; Transcription initiation complex Chromosomal Location of Human Ortholog: 2p25 Cellular Component: nucleoplasm Molecular Function:protein binding; TATA-binding protein binding Biological Process: positive regulation of gene expression, epigenetic; RNA elongation from RNA polymerase I promoter; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoter |
NCBI Summary: | Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] |
UniProt Code: | Q53T94 |
NCBI GenInfo Identifier: | 74726856 |
NCBI Gene ID: | 9014 |
NCBI Accession: | Q53T94.1 |
UniProt Secondary Accession: | Q53T94,Q15574, Q8WVC3, B4DI42, F8WD72, |
UniProt Related Accession: | Q53T94 |
Molecular Weight: | 39,533 Da |
NCBI Full Name: | TATA box-binding protein-associated factor RNA polymerase I subunit B |
NCBI Synonym Full Names: | TATA-box binding protein associated factor, RNA polymerase I subunit B |
NCBI Official Symbol: | TAF1B |
NCBI Official Synonym Symbols: | SL1; RAF1B; RAFI63; TAFI63; MGC:9349 |
NCBI Protein Information: | TATA box-binding protein-associated factor RNA polymerase I subunit B |
UniProt Protein Name: | TATA box-binding protein-associated factor RNA polymerase I subunit B |
UniProt Synonym Protein Names: | RNA polymerase I-specific TBP-associated factor 63 kDa; TAFI63; TATA box-binding protein-associated factor 1B; TBP-associated factor 1B; Transcription initiation factor SL1/TIF-IB subunit B |
Protein Family: | Transcription initiation factor |
UniProt Gene Name: | TAF1B |
UniProt Entry Name: | TAF1B_HUMAN |