STXBP3 Antibody (PACO51986)
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주문- SKU:
- PACO51986
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | STXBP3 Antibody (PACO51986) |
Antibody SKU: | PACO51986 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Syntaxin-binding protein 3 protein (266-528AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: Mouse kidney tissue. All lanes: STXBP3 antibody at 3.4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 68 kDa. Observed band size: 68 kDa. |
![]() | Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO51986 at dilution of 1:100. |
Background: | Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. |
Synonyms: | Syntaxin-binding protein 3 (Platelet Sec1 protein) (PSP) (Protein unc-18 homolog 3) (Unc18-3) (Protein unc-18 homolog C) (Unc-18C), STXBP3 |
UniProt Protein Function: | STXBP3: a vesicle protein that, together with STX4 and VAMP2, regulates the insulin-dependent movement of GLUT4 and the docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. Reduction in its expression using siRNA impairs insulin-stimulated GLUT4 vesicle exocytosis in 3T3-L1 adipocytes. Phosphorylated by the insulin receptor (InsR) at Tyr521 in vitro, and bound and phosphorylated by the activated InsR within adipocytes and skeletal muscle. Tyrosine phosphorylation on residues Y219 and Y521 correlates with its dissociation from STX4. Phosphorylated by PKC in platelets in response to thrombin stimulation, inhibiting its binding to STX4. Interacts directly with DOC2B at the cell membrane, excluding its interaction with STX4, regulating glucose-stimulated insulin secretion. Belongs to the STXBP/unc-18/SEC1 family. |
UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 1p13.3 Cellular Component: cytosol; plasma membrane; specific granule Molecular Function:protein binding; syntaxin binding Biological Process: negative regulation of calcium ion-dependent exocytosis; neutrophil degranulation |
UniProt Code: | O00186 |
NCBI GenInfo Identifier: | 206729898 |
NCBI Gene ID: | 6814 |
NCBI Accession: | O00186.2 |
UniProt Secondary Accession: | O00186,Q53FW1, Q86YJ3, Q9UPD7, A8K269, A8K5K7, |
UniProt Related Accession: | O00186 |
Molecular Weight: | 67,764 Da |
NCBI Full Name: | Syntaxin-binding protein 3 |
NCBI Synonym Full Names: | syntaxin binding protein 3 |
NCBI Official Symbol: | STXBP3 |
NCBI Official Synonym Symbols: | PSP; MUNC18C; UNC-18C; MUNC18-3 |
NCBI Protein Information: | syntaxin-binding protein 3 |
UniProt Protein Name: | Syntaxin-binding protein 3 |
UniProt Synonym Protein Names: | Platelet Sec1 protein; PSP; Protein unc-18 homolog 3; Unc18-3; Protein unc-18 homolog C; Unc-18C |
Protein Family: | Syntaxin-binding protein |
UniProt Gene Name: | STXBP3 |
UniProt Entry Name: | STXB3_HUMAN |