STXBP2 Antibody (PACO44982)
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주문- SKU:
- PACO44982
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | STXBP2 Antibody (PACO44982) |
Antibody SKU: | PACO44982 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Syntaxin-binding protein 2 protein (1-280AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: STXBP2 antibody at 4.1µg/ml. Lane 1: Mouse gonadal tissue. Lane 2: Jurkat whole cell lysate. Lane 3: A549 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 67, 68 kDa. Observed band size: 67 kDa.. | |
Immunohistochemistry of paraffin-embedded human liver tissue using PACO44982 at dilution of 1:100. |
Background: | Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells. |
Synonyms: | Syntaxin-binding protein 2 (Protein unc-18 homolog 2) (Unc18-2) (Protein unc-18 homolog B) (Unc-18B), STXBP2, UNC18B |
UniProt Protein Function: | STXBP2: Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N- ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells. Defects in STXBP2 are the cause of familial hemophagocytic lymphohistiocytosis type 5 (FHL5). FHL5 is rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia. Belongs to the STXBP/unc-18/SEC1 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 19p13.3-p13.2 Cellular Component: SNARE complex; specific granule; azurophil granule; plasma membrane; cytosol Molecular Function:protein binding; syntaxin-3 binding Biological Process: regulation of mast cell degranulation; protein transport; leukocyte mediated cytotoxicity; neutrophil degranulation; vesicle docking during exocytosis Disease: Hemophagocytic Lymphohistiocytosis, Familial, 5 |
NCBI Summary: | This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2013] |
UniProt Code: | Q15833 |
NCBI GenInfo Identifier: | 313104015 |
NCBI Gene ID: | 6813 |
NCBI Accession: | Q15833.2 |
UniProt Secondary Accession: | Q15833,Q9BU65, B4E175, E7EQD5, |
UniProt Related Accession: | Q15833 |
Molecular Weight: | 593 |
NCBI Full Name: | Syntaxin-binding protein 2 |
NCBI Synonym Full Names: | syntaxin binding protein 2 |
NCBI Official Symbol: | STXBP2 |
NCBI Official Synonym Symbols: | FHL5; UNC18B; Hunc18b; UNC18-2; pp10122; MUNC18-2 |
NCBI Protein Information: | syntaxin-binding protein 2; unc-18B; protein unc-18 homolog B |
UniProt Protein Name: | Syntaxin-binding protein 2 |
UniProt Synonym Protein Names: | Protein unc-18 homolog 2; Unc18-2; Protein unc-18 homolog B; Unc-18B |
Protein Family: | Syntaxin-binding protein |
UniProt Gene Name: | STXBP2 |
UniProt Entry Name: | STXB2_HUMAN |