STMN2 Antibody (PACO50910)
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주문- SKU:
- PACO50910
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | STMN2 Antibody (PACO50910) |
Antibody SKU: | PACO50910 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Stathmin-2 protein (61-129AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO50910 at dilution of 1:100. |
![]() | Immunofluorescent analysis of A549 cells using PACO50910 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
![]() | Immunohistochemistry of paraffin-embedded human brain tissue using PACO50910 at dilution of 1:100. |
Background: | Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity). |
Synonyms: | Stathmin-2 (Superior cervical ganglion-10 protein) (Protein SCG10), STMN2, SCG10 SCGN10 |
UniProt Protein Function: | STMN2: a cytoskeletal protein that may play a role in neuronal differentiation, and in modulating membrane interaction with the cytoskeleton during neurite outgrowth. Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. Neuron specific. |
UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 8q21.13 Cellular Component: cell soma; cytoplasm; growth cone; lamellipodium; neuron projection; perinuclear region of cytoplasm Molecular Function:calcium-dependent protein binding; protein binding; tubulin binding Biological Process: negative regulation of microtubule depolymerization; negative regulation of microtubule polymerization; positive regulation of microtubule depolymerization |
NCBI Summary: | This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010] |
UniProt Code: | Q93045 |
NCBI GenInfo Identifier: | 51704330 |
NCBI Gene ID: | 11075 |
NCBI Accession: | Q93045.3 |
UniProt Secondary Accession: | Q93045,O14952, Q6PK68, A8K9M2, G3V110, |
UniProt Related Accession: | Q93045 |
Molecular Weight: | 21,802 Da |
NCBI Full Name: | Stathmin-2 |
NCBI Synonym Full Names: | stathmin 2 |
NCBI Official Symbol: | STMN2 |
NCBI Official Synonym Symbols: | SCG10; SCGN10 |
NCBI Protein Information: | stathmin-2 |
UniProt Protein Name: | Stathmin-2 |
UniProt Synonym Protein Names: | Superior cervical ganglion-10 protein; Protein SCG10 |
Protein Family: | Stathmin |
UniProt Gene Name: | STMN2 |
UniProt Entry Name: | STMN2_HUMAN |