STARD5 Antibody (PACO20612)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO20612
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | STARD5 Antibody (PACO20612) |
Antibody SKU: | PACO20612 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:40-1:150 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human STARD5 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Gel: 12%SDS-PAGE, Lysate: 40 µg, Lane: Human fetal brain tissue, Primary antibody: PACO20612(STARD5 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20612(STARD5 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. |
Synonyms: | StAR-related lipid transfer (START) domain containing 5 |
UniProt Protein Function: | STARD5: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 15q26 Cellular Component: cytosol Biological Process: C21-steroid hormone biosynthetic process |
NCBI Summary: | Proteins containing a steroidogenic acute regulatory-related lipid transfer (START) domain are often involved in the trafficking of lipids and cholesterol between diverse intracellular membranes. This gene is a member of the StarD subfamily that encodes START-related lipid transfer proteins. The protein encoded by this gene is a cholesterol transporter and is also able to bind and transport other sterol-derived molecules related to the cholesterol/bile acid biosynthetic pathways such as 25-hydroxycholesterol. Its expression is upregulated during endoplasmic reticulum (ER) stress. The protein is thought to act as a cytosolic sterol transporter that moves cholesterol between intracellular membranes such as from the cytoplasm to the ER and from the ER to the Golgi apparatus. Alternative splicing of this gene produces multiple transcript variants. [provided by RefSeq, Jan 2016] |
UniProt Code: | Q9NSY2 |
NCBI GenInfo Identifier: | 25091329 |
NCBI Gene ID: | 80765 |
NCBI Accession: | Q9NSY2.2 |
UniProt Secondary Accession: | Q9NSY2,P59094, |
UniProt Related Accession: | Q9NSY2 |
Molecular Weight: | 7,094 Da |
NCBI Full Name: | StAR-related lipid transfer protein 5 |
NCBI Synonym Full Names: | StAR related lipid transfer domain containing 5 |
NCBI Official Symbol: | STARD5 |
NCBI Protein Information: | stAR-related lipid transfer protein 5 |
UniProt Protein Name: | StAR-related lipid transfer protein 5 |
UniProt Synonym Protein Names: | START domain-containing protein 5; StARD5 |
Protein Family: | StAR-related lipid transfer protein |
UniProt Gene Name: | STARD5 |
UniProt Entry Name: | STAR5_HUMAN |