SSB Antibody (PACO20604)
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주문- SKU:
- PACO20604
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SSB Antibody (PACO20604) |
Antibody SKU: | PACO20604 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human SSB |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO20604(SSB Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane 1-4: K562 cells, 231 cells, Raji cells, hela cells, Primary antibody: PACO20604(SSB Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20604(SSB Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. |
Synonyms: | Sjogren syndrome antigen B (autoantigen La) |
UniProt Protein Function: | SSB: a nuclear protein that plays a role in the transcription of RNA polymerase III. It is most probably a transcription termination factor. Binds to the 3' termini of virtually all nascent polymerase III transcripts. It is associated with precursor forms of RNA polymerase III transcripts including tRNA and 4.5S, 5s, 7s, and 7-2 RNAs. |
UniProt Protein Details: | Protein type:Transcription initiation complex Chromosomal Location of Human Ortholog: 2q31.1 Cellular Component: nuclear chromosome, telomeric region; ribonucleoprotein complex Molecular Function:mRNA binding; nucleotide binding; protein binding; tRNA binding Biological Process: histone mRNA metabolic process; tRNA modification |
NCBI Summary: | The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014] |
UniProt Code: | P05455 |
NCBI GenInfo Identifier: | 125985 |
NCBI Gene ID: | 6741 |
NCBI Accession: | P05455.2 |
UniProt Secondary Accession: | P05455,Q15367, Q53XJ4, |
UniProt Related Accession: | P05455 |
Molecular Weight: | 46,837 Da |
NCBI Full Name: | Lupus La protein |
NCBI Synonym Full Names: | Sjogren syndrome antigen B |
NCBI Official Symbol: | SSB |
NCBI Official Synonym Symbols: | La; LARP3; La/SSB |
NCBI Protein Information: | lupus La protein |
UniProt Protein Name: | Lupus La protein |
UniProt Synonym Protein Names: | La autoantigen; La ribonucleoprotein; Sjoegren syndrome type B antigen; SS-B |
Protein Family: | Lupus La protein |
UniProt Gene Name: | SSB |
UniProt Entry Name: | LA_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |