SLC1A6 Antibody (PACO17811)
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주문- SKU:
- PACO17811
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SLC1A6 Antibody (PACO17811) |
Antibody SKU: | PACO17811 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human SLC1A6 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO17811(SLC1A6 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human testis tissue, A375 cells, Primary antibody: PACO17811(SLC1A6 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17811(SLC1A6 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | Excitatory Amino acid, Transporters (EAATs) are membrane-bound proteins that are localized in glial cells and pre-synaptic glutamatergic nerve endings. EAATs transport the excitatory neurotransmitters L-glutamate and D-aspartate, a process that is essential for terminating the postsynaptic action of glutamate. The re-uptake of amino acid, neurotransmitters by EAAT proteins has been shown to protect neurons from excitotoxicity, which is caused by the accumulation of amino acid, neurotransmitters. EAAT4 is an aspartate/glutamate transporter that is expressed predominantly in the cerebellum. The transport activity encoded by EAAT4 has high apparent affinity for L-aspartate and L-glutamate, and has a pharmacologic profile consistent with previously described cerebellar transport activities. EAAT5 is a glutamate transporter coupled to a chloride conductance which is expressed primarily in retina. Although EAAT5 shares the structural homologies of the EAAT family, a novel feature of the EAAT5 sequence is a carboxy-terminal motif previously identified in N-ethyl-D-aspartate receptors and potassium channels and shown to confer interactions with a family of synaptic proteins that promote ion channel clustering. |
Synonyms: | solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 |
UniProt Protein Function: | SLC1A6: Transports L-glutamate and also L- and D-aspartate. Seems to act as a symport by cotransporting sodium. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A6 subfamily. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Transporter; Transporter, SLC family; Membrane protein, integral Chromosomal Location of Human Ortholog: 19p13.12 Cellular Component: Golgi apparatus; membrane; integral to plasma membrane; plasma membrane Molecular Function:L-aspartate transmembrane transporter activity; sodium:dicarboxylate symporter activity; L-glutamate transmembrane transporter activity Biological Process: synaptic transmission; regulation of membrane potential; L-glutamate transport; ion transport; aspartate transport; transmembrane transport |
UniProt Code: | P48664 |
NCBI GenInfo Identifier: | 1352333 |
NCBI Gene ID: | 6511 |
NCBI Accession: | P48664.1 |
UniProt Secondary Accession: | P48664,Q8N753, |
UniProt Related Accession: | P48664 |
Molecular Weight: | 564 |
NCBI Full Name: | Excitatory amino acid transporter 4 |
NCBI Synonym Full Names: | solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 |
NCBI Official Symbol: | SLC1A6 |
NCBI Official Synonym Symbols: | EAAT4 |
NCBI Protein Information: | excitatory amino acid transporter 4; solute carrier family 1 member 6; sodium-dependent glutamate/aspartate transporter |
UniProt Protein Name: | Excitatory amino acid transporter 4 |
UniProt Synonym Protein Names: | Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6 |
Protein Family: | Excitatory amino acid transporter |
UniProt Gene Name: | SLC1A6 |
UniProt Entry Name: | EAA4_HUMAN |