SIGLEC5 Antibody (PACO15958)
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주문- SKU:
- PACO15958
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SIGLEC5 Antibody (PACO15958) |
Antibody SKU: | PACO15958 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human SIGLEC5 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO15958(SIGLEC5 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15958(SIGLEC5 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene encodes a member of the sialic acid, binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid, recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. |
Synonyms: | sialic acid, binding Ig-like lectin 5 |
UniProt Protein Function: | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. |
NCBI Summary: | This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012] |
UniProt Code: | O15389 |
NCBI GenInfo Identifier: | 25009254 |
NCBI Gene ID: | 8778 |
NCBI Accession: | O15389.1 |
UniProt Related Accession: | O15389 |
Molecular Weight: | 60,715 Da |
NCBI Full Name: | Sialic acid-binding Ig-like lectin 5 |
NCBI Synonym Full Names: | sialic acid binding Ig like lectin 5 |
NCBI Official Symbol: | SIGLEC5 |
NCBI Official Synonym Symbols: | CD170; OBBP2; CD33L2; OB-BP2; SIGLEC-5 |
NCBI Protein Information: | sialic acid-binding Ig-like lectin 5 |
UniProt Protein Name: | Sialic acid-binding Ig-like lectin 5 |
UniProt Synonym Protein Names: | CD33 antigen-like 2; Obesity-binding protein 2; OB-BP2; OB-binding protein 2; CD_antigen: CD170 |
UniProt Gene Name: | SIGLEC5 |