UniProt Protein Function: | SGK2: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up- regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Highly expressed in liver, kidney and pancreas, and at lower levels in brain. Two specific sites, one in the kinase domain (Thr-253) and the other in the C-terminal regulatory region (Ser- 416), need to be phsphorylated for its full activation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, AGC; AGC group; SGK family Chromosomal Location of Human Ortholog: 20q13.2 Cellular Component: cytosol; intracellular; nucleus Molecular Function:ATP binding; calcium channel regulator activity; chloride channel regulator activity; potassium channel regulator activity; protein serine/threonine kinase activity; sodium channel regulator activity Biological Process: cellular sodium ion homeostasis; peptidyl-serine phosphorylation; positive regulation of transporter activity; protein amino acid phosphorylation; regulation of apoptosis; regulation of cell growth; regulation of cell proliferation; response to oxidative stress |
NCBI Summary: | This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010] |
UniProt Code: | Q9HBY8 |
NCBI GenInfo Identifier: | 28558166 |
NCBI Gene ID: | 10110 |
NCBI Accession: | Q9HBY8.1 |
UniProt Secondary Accession: | Q9HBY8,Q52PK5, Q5H8Y6, Q5H8Z1, Q5TZR3, Q9UKG6, |
UniProt Related Accession: | Q9HBY8 |
Molecular Weight: | 43,977 Da |
NCBI Full Name: | Serine/threonine-protein kinase Sgk2 |
NCBI Synonym Full Names: | SGK2, serine/threonine kinase 2 |
NCBI Official Symbol: | SGK2 |
NCBI Official Synonym Symbols: | H-SGK2; dJ138B7.2 |
NCBI Protein Information: | serine/threonine-protein kinase Sgk2 |
UniProt Protein Name: | Serine/threonine-protein kinase Sgk2 |
UniProt Synonym Protein Names: | Serum/glucocorticoid-regulated kinase 2 |
Protein Family: | Serine/threonine-protein kinase |
UniProt Gene Name: | SGK2 |
UniProt Entry Name: | SGK2_HUMAN |