SERPINB6 Antibody (PACO45575)
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주문- SKU:
- PACO45575
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SERPINB6 Antibody (PACO45575) |
Antibody SKU: | PACO45575 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Serpin B6 protein (180-300AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: SERPINB6 antibody at 0.95 µg/ml. Lane 1: Human placenta tissue. Lane 2: HepG2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 43 kDa. Observed band size: 43, 36 kDa.. |
![]() | Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO45575 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO45575 at dilution of 1:100. |
Background: | May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. |
Synonyms: | Serpin B6 (Cytoplasmic antiproteinase) (CAP) (Peptidase inhibitor 6) (PI-6) (Placental thrombin inhibitor), SERPINB6, PI6 PTI |
UniProt Protein Function: | May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. |
NCBI Summary: | The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010] |
UniProt Code: | P35237 |
NCBI GenInfo Identifier: | 425876796 |
NCBI Gene ID: | 5269 |
NCBI Accession: | NP_001182220.2 |
UniProt Secondary Accession: | P35237,Q59F97, Q5TD06, Q7Z2Y7, Q96J44, Q9UDI7, B2RBA8 |
UniProt Related Accession: | P35237 |
Molecular Weight: | 42,622 Da |
NCBI Full Name: | serpin B6 isoform b |
NCBI Synonym Full Names: | serpin family B member 6 |
NCBI Official Symbol: | SERPINB6 |
NCBI Official Synonym Symbols: | CAP; PI6; PTI; PI-6; SPI3; DFNB91; MSTP057 |
NCBI Protein Information: | serpin B6 |
UniProt Protein Name: | Serpin B6 |
UniProt Synonym Protein Names: | Cytoplasmic antiproteinase; CAP; Peptidase inhibitor 6; PI-6; Placental thrombin inhibitor |
UniProt Gene Name: | SERPINB6 |
Antibodies | ELISA Kits |
Anti-Serpin B6 Antibody (CAB9944) | Human Serpin B6 ELISA Kit |
SERPINB6 Antibody (PACO12115) | Human Serpin B6 (SERPINB6) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |