SEC14L2 Antibody (PACO20417)
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주문- SKU:
- PACO20417
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SEC14L2 Antibody (PACO20417) |
Antibody SKU: | PACO20417 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human SEC14L2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20417(SEC14L2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane 1-3: Mouse liver tissue, PC3 cells, human fetal liver tissue, Primary antibody: PACO20417(SEC14L2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20417(SEC14L2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. |
Synonyms: | SEC14-like 2 |
UniProt Protein Function: | SEC14L2: Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Lipid-binding Chromosomal Location of Human Ortholog: 22q12.2 Cellular Component: cytosol; nucleus |
NCBI Summary: | This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008] |
UniProt Code: | O76054 |
NCBI GenInfo Identifier: | 21542232 |
NCBI Gene ID: | 23541 |
NCBI Accession: | O76054.1 |
UniProt Secondary Accession: | O76054,Q53EQ2, Q6PD61, Q9ULN4, B7Z8Q1, F5H3U4, |
UniProt Related Accession: | O76054 |
Molecular Weight: | 46kDa |
NCBI Full Name: | SEC14-like protein 2 |
NCBI Synonym Full Names: | SEC14 like lipid binding 2 |
NCBI Official Symbol: | SEC14L2 |
NCBI Official Synonym Symbols: | SPF; TAP; TAP1; C22orf6 |
NCBI Protein Information: | SEC14-like protein 2 |
UniProt Protein Name: | SEC14-like protein 2 |
UniProt Synonym Protein Names: | Alpha-tocopherol-associated protein; TAP; hTAP; Squalene transfer protein; Supernatant protein factor; SPF |
Protein Family: | SEC14-like protein |
UniProt Gene Name: | SEC14L2 |
Antibodies |
Anti-SEC14L2 Antibody (CAB10586) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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