SCYL1 Antibody (PACO44913)
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주문- SKU:
- PACO44913
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SCYL1 Antibody (PACO44913) |
Antibody SKU: | PACO44913 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human N-terminal kinase-like protein (460-740AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: SCYL1 antibody at 3.15 µg/ml. Lane 1: 293T whole cell lysate. Lane 2: Hela whole cell lysate. Lane 3: 3T3 whole cell lysate. Lane 4: A549 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 90, 89, 79, 87, 70 kDa. Observed band size: 90, 110 kDa.. |
Background: | Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro. |
Synonyms: | N-terminal kinase-like protein (Coated vesicle-associated kinase of 90 kDa) (SCY1-like protein 1) (Telomerase regulation-associated protein) (Telomerase transcriptional element-interacting factor) (Teratoma-associated tyrosine kinase), SCYL1, CVAK90 GKLP NTKL TAPK TEIF TRAP |
UniProt Protein Function: | SCYL1: Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro. Belongs to the protein kinase superfamily. 6 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; SCY1 family Chromosomal Location of Human Ortholog: 11q13 Cellular Component: Golgi apparatus; cis-Golgi network; membrane; cytoplasm; ER-Golgi intermediate compartment; microtubule organizing center; COPI vesicle coat; nucleus Molecular Function:DNA binding; protein-tyrosine kinase activity; ATP binding Biological Process: peptidyl-tyrosine phosphorylation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; retrograde vesicle-mediated transport, Golgi to ER |
NCBI Summary: | This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q96KG9 |
NCBI GenInfo Identifier: | 74762671 |
NCBI Gene ID: | 57410 |
NCBI Accession: | Q96KG9.1 |
UniProt Secondary Accession: | Q96KG9,Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53 A6NJF1, |
UniProt Related Accession: | Q96KG9 |
Molecular Weight: | 808 |
NCBI Full Name: | N-terminal kinase-like protein |
NCBI Synonym Full Names: | SCY1-like 1 (S. cerevisiae) |
NCBI Official Symbol: | SCYL1 |
NCBI Official Synonym Symbols: | GKLP; NKTL; NTKL; P105; TAPK; TEIF; TRAP; HT019 |
NCBI Protein Information: | N-terminal kinase-like protein; SCY1-like protein 1; teratoma-associated tyrosine kinase; telomerase regulation-associated protein; coated vesicle-associated kinase of 90 kDa; telomerase transcriptional element-interacting factor; telomerase transcriptional elements-interacting factor; likely ortholog of mouse N-terminal kinase-like protein |
UniProt Protein Name: | N-terminal kinase-like protein |
UniProt Synonym Protein Names: | Coated vesicle-associated kinase of 90 kDa; SCY1-like protein 1; Telomerase regulation-associated protein; Telomerase transcriptional element-interacting factor; Teratoma-associated tyrosine kinase |
Protein Family: | N-terminal kinase-like protein |
UniProt Gene Name: | SCYL1 |
UniProt Entry Name: | NTKL_HUMAN |