SAT1 Antibody (PACO31548)
- SKU:
- PACO31548
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SAT1 Antibody (PACO31548) |
Antibody SKU: | PACO31548 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Diamine acetyltransferase 1 protein (5-171AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot All lanes: SAT1 antibody at 2µg/ml Lane 1: 293T whole cell lysate Lane 2: EC109 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/15000 dilution Predicted band size: 21 kDa Observed band size: 90 kDa . |
![]() | Immunohistochemistry of paraffin-embedded human testis tissue using PACO31548 at dilution of 1:100. |
Synonyms: | Diamine acetyltransferase 1 (EC 2.3.1.57) (Polyamine N-acetyltransferase 1) (Putrescine acetyltransferase) (Spermidine/spermine N(1)-acetyltransferase 1) (SSAT) (SSAT-1), SAT1, SAT |
UniProt Protein Function: | SAT: Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine. Defects in SAT1 may be a cause of keratosis follicularis spinulosa decalvans X-linked (KFSDX). A rare disorder affecting the skin and the eye. Affected men show thickening of the skin of the neck, ears, and extremities, especially the palms and soles, loss of eyebrows, eyelashes and beard, thickening of the eyelids with blepharitis and ectropion, and corneal degeneration. Belongs to the acetyltransferase family. |
UniProt Protein Details: | Protein type:Amino Acid Metabolism - arginine and proline; EC 2.3.1.57; Acetyltransferase Chromosomal Location of Human Ortholog: Xp22.1 Cellular Component: intracellular; cytosol Molecular Function:protein binding; diamine N-acetyltransferase activity; spermidine binding Biological Process: spermidine acetylation; polyamine biosynthetic process; angiogenesis; putrescine catabolic process; polyamine metabolic process; regulation of cell proliferation Disease: Keratosis Follicularis Spinulosa Decalvans, X-linked |
NCBI Summary: | The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.[provided by RefSeq, Sep 2009] |
UniProt Code: | P21673 |
NCBI GenInfo Identifier: | 114322 |
NCBI Gene ID: | 6303 |
NCBI Accession: | P21673.1 |
UniProt Related Accession: | P21673 |
Molecular Weight: | 171 |
NCBI Full Name: | Diamine acetyltransferase 1 |
NCBI Synonym Full Names: | spermidine/spermine N1-acetyltransferase 1 |
NCBI Official Symbol: | SAT1 |
NCBI Official Synonym Symbols: | SAT; DC21; KFSD; SSAT; KFSDX; SSAT-1 |
NCBI Protein Information: | diamine acetyltransferase 1; putrescine acetyltransferase; diamine N-acetyltransferase 1; polyamine N-acetyltransferase 1; spermidine/spermine N1-acetyltransferase alpha |
UniProt Protein Name: | Diamine acetyltransferase 1 |
UniProt Synonym Protein Names: | Polyamine N-acetyltransferase 1; Putrescine acetyltransferase; Spermidine/spermine N(1)-acetyltransferase 1; SSAT; SSAT-1 |
Protein Family: | Serine acetyltransferase |
UniProt Gene Name: | SAT1 |
UniProt Entry Name: | SAT1_HUMAN |