SAR1B Antibody (PACO23440)
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주문- SKU:
- PACO23440
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | SAR1B Antibody (PACO23440) |
Antibody SKU: | PACO23440 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthesized peptide derived from internal of human SAR1B. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot analysis of extracts from LOVO cells and RAW264.7 cells, using SAR1B antibody. |
![]() | Immunohistochemistry analysis of paraffin-embedded human placenta tissue using SAR1B antibody. |
Background: | Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex. |
Synonyms: | GTP-binding protein SAR1b; GTBPB; SAR1B; SARA2; SARB |
UniProt Protein Function: | SAR1B: Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex. Defects in SAR1B are the cause of chylomicron retention disease (CMRD); also known as Anderson disease (ANDD). CMRD is an autosomal recessive disorder of severe fat malabsorption associated with failure to thrive in infancy. The condition is characterized by deficiency of fat-soluble vitamins, low blood cholesterol levels, and a selective absence of chylomicrons from blood. Affected individuals accumulate chylomicron-like particles in membrane-bound compartments of enterocytes, which contain large cytosolic lipid droplets. Belongs to the small GTPase superfamily. SAR1 family. |
UniProt Protein Details: | Protein type:G protein; G protein, monomeric, SAR1; G protein, monomeric; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 5q31.1 Cellular Component: cytosol; endoplasmic reticulum membrane Molecular Function:GTP binding; GTPase activity; metal ion binding Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; intracellular protein transport; post-translational protein modification; protein amino acid N-linked glycosylation via asparagine Disease: Chylomicron Retention Disease |
NCBI Summary: | The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010] |
UniProt Code: | Q9Y6B6 |
NCBI GenInfo Identifier: | 14285769 |
NCBI Gene ID: | 51128 |
NCBI Accession: | Q9Y6B6.1 |
UniProt Secondary Accession: | Q9Y6B6,Q567T4, D3DQA4, |
UniProt Related Accession: | Q9Y6B6 |
Molecular Weight: | 22,410 Da |
NCBI Full Name: | GTP-binding protein SAR1b |
NCBI Synonym Full Names: | secretion associated Ras related GTPase 1B |
NCBI Official Symbol: | SAR1B |
NCBI Official Synonym Symbols: | ANDD; CMRD; GTBPB; SARA2 |
NCBI Protein Information: | GTP-binding protein SAR1b |
UniProt Protein Name: | GTP-binding protein SAR1b |
UniProt Synonym Protein Names: | GTP-binding protein B; GTBPB |
Protein Family: | GTP-binding protein |
UniProt Gene Name: | SAR1B |
UniProt Entry Name: | SAR1B_HUMAN |