RRAGC Antibody (PACO44549)
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주문- SKU:
- PACO44549
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | RRAGC Antibody (PACO44549) |
Antibody SKU: | PACO44549 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Ras-related GTP-binding protein C protein (1-250AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: RRAGC antibody at 1.14µg/ml. Lane 1: Hela whole cell lysate. Lane 2: MCF-7 whole cell lysate. Lane 3: A549 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 44 kDa. Observed band size: 44 kDa.. | |
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO44549 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO44549 at dilution of 1:100. |
Background: | Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid, induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acid,. |
Synonyms: | Ras-related GTP-binding protein C (Rag C) (RagC) (GTPase-interacting protein 2) (TIB929), RRAGC |
UniProt Protein Function: | RRAGC: Has guanine nucleotide-binding activity but weak intrinsic GTPase activity. Probably required for the amino acid- induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Forms a heterodimer with RRAGA in a sequence-independent manner. Binds GTP. Interacts with NOL8 and RRAGB. Belongs to the GTR/RAG GTP-binding protein family. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1p34 Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; lysosome; nucleus Molecular Function:GDP binding; GTP binding; GTPase activity; magnesium ion binding; protein binding; protein heterodimerization activity Biological Process: apoptosis; cell cycle arrest; cell growth; cellular response to amino acid starvation; gene expression; insulin receptor signaling pathway; macroautophagy; regulation of TOR signaling pathway; RNA splicing; small GTPase mediated signal transduction; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent |
NCBI Summary: | This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012] |
UniProt Code: | Q9HB90 |
NCBI GenInfo Identifier: | 74752776 |
NCBI Gene ID: | 64121 |
NCBI Accession: | Q9HB90.1 |
UniProt Secondary Accession: | Q9HB90,Q9H202, Q9H8Q8, |
UniProt Related Accession: | Q9HB90 |
Molecular Weight: | 44,224 Da |
NCBI Full Name: | Ras-related GTP-binding protein C |
NCBI Synonym Full Names: | Ras related GTP binding C |
NCBI Official Symbol: | RRAGC |
NCBI Official Synonym Symbols: | GTR2; RAGC; TIB929 |
NCBI Protein Information: | ras-related GTP-binding protein C |
UniProt Protein Name: | Ras-related GTP-binding protein C |
UniProt Synonym Protein Names: | GTPase-interacting protein 2; TIB929 |
Protein Family: | Ras-related GTP-binding protein |
UniProt Gene Name: | RRAGC |
UniProt Entry Name: | RRAGC_HUMAN |