RPIA Antibody (PACO64051)
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주문- SKU:
- PACO64051
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | RPIA Antibody (PACO64051) |
Antibody SKU: | PACO64051 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:200-1:500 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Ribose-5-phosphate isomerase protein (1-311AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Antigen Affinity purified & Affinity purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: HepG2 whole cell lysate, K562 whole cell lysate, U251 whole cell lysate, MCF-7 whole cell lysate, PC-3 whole cell lysate. All lanes: RPIA antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 34 kDa. Observed band size: 33 kDa. |
![]() | IHC image of PACO64051 diluted at 1:400 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG labeled by HRP and visualized using 0.05% DAB. |
Background: | cytosol, intracellular membrane-bounded organelle, identical protein binding, ribose-5-phosphate isomerase activity, D-ribose metabolic process, pentose-phosphate shunt, pentose-phosphate shunt, non-oxidative branch |
Synonyms: | Ribose-5-phosphate isomerase (EC 5.3.1.6) (Phosphoriboisomerase), RPIA, RPI |
UniProt Protein Function: | RPIA: Defects in RPIA are the cause of ribose 5-phosphate isomerase deficiency (RPID). A patient has been described with a deficiency of ribose 5-phosphate isomerase who presented with leukoencephalopathy and peripheral neuropathy. Proton magnetic resonance spectroscopy of the brain revealed a highly elevated level of the polyols ribitol and D-arabitol, which were subsequently also found in high concentrations in body fluids. Deficient activity of RPIA, one of the pentose phosphate pathway enzymes, has been demonstrated in fibroblasts. Belongs to the ribose 5-phosphate isomerase family. |
UniProt Protein Details: | Protein type:EC 5.3.1.6; Isomerase; Carbohydrate Metabolism - pentose phosphate pathway Chromosomal Location of Human Ortholog: 2p11.2 Cellular Component: cytosol Molecular Function:protein binding; ribose-5-phosphate isomerase activity Biological Process: pentose-phosphate shunt Disease: Ribose 5-phosphate Isomerase Deficiency |
NCBI Summary: | The protein encoded by this gene is an enzyme, which catalyzes the reversible conversion between ribose-5-phosphate and ribulose-5-phosphate in the pentose-phosphate pathway. This gene is highly conserved in most organisms. The enzyme plays an essential role in the carbohydrate metabolism. Mutations in this gene cause ribose 5-phosphate isomerase deficiency. A pseudogene is found on chromosome 18. [provided by RefSeq, Mar 2010] |
UniProt Code: | P49247 |
NCBI GenInfo Identifier: | 156637353 |
NCBI Gene ID: | 22934 |
NCBI Accession: | P49247.3 |
UniProt Secondary Accession: | P49247,Q541P9, Q96BJ6, |
UniProt Related Accession: | P49247 |
Molecular Weight: | 33,269 Da |
NCBI Full Name: | Ribose-5-phosphate isomerase |
NCBI Synonym Full Names: | ribose 5-phosphate isomerase A |
NCBI Official Symbol: | RPIA |
NCBI Official Synonym Symbols: | RPI; RPIAD |
NCBI Protein Information: | ribose-5-phosphate isomerase |
UniProt Protein Name: | Ribose-5-phosphate isomerase |
UniProt Synonym Protein Names: | Phosphoriboisomerase |
Protein Family: | Ribose-5-phosphate isomerase |
UniProt Gene Name: | RPIA |
UniProt Entry Name: | RPIA_HUMAN |
Antibodies | ELISA Kits |
Anti-RPIA Antibody (CAB8867) | Human RPIA / Ribose-5-phosphate isomerase ELISA Kit |
RPIA Antibody (PACO11904) | Human Ribose-5-phosphate isomerase (RPIA) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |