ROS1 Antibody (PACO51066)
- SKU:
- PACO51066
- Product type:
- Antibody
- Reactivity:
- Arabidopsis thaliana
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | ROS1 Antibody (PACO51066) |
| Antibody SKU: | PACO51066 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Arabidopsis thaliana |
| Immunogen: | Recombinant Arabidopsis thaliana Protein ROS1 protein (1-320AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Bifunctional DNA glycosylase/lyase, which excises 5-methylcytosine (5-meC) and 5-hydroxymethylcytosine (5-hmeC), leaving an apyrimidinic (AP) site that is subsequently incised by the lyase activity. Generates 3'-phosphor-alpha,beta-unsaturated aldehyde (3'-PUA) as a primary 5-meC excision intermediate. Prevents DNA hypermethylation, specifically in the promoter of otherwise silenced loci. May be involved in DNA repair through its nicking activity on methylated DNA. Binds with similar affinity to both methylated and non-methylated DNA. Highly distributive behavior on DNA substrates containing multiple 5-meC residues. Involved with Pol IV in the remodeling of the 5S rDNA chromatin via DNA methylation modifications during the first days of development post-germination. Participates in UV-B induced- and oxidative DNA damage repair. |
| Synonyms: | Protein ROS1 (EC 3.2.2) (DEMETER-like protein 1) (Repressor of silencing 1), ROS1, DML1 |
| UniProt Protein Function: | Bifunctional DNA glycosylase/lyase, which excises 5-methylcytosine (5-meC) and 5-hydroxymethylcytosine (5-hmeC), leaving an apyrimidinic (AP) site that is subsequently incised by the lyase activity (PubMed:25240767). Generates 3'-phosphor-alpha,beta-unsaturated aldehyde (3'-PUA) as a primary 5-meC excision intermediate (PubMed:25228464). Prevents DNA hypermethylation, specifically in the promoter of otherwise silenced loci. May be involved in DNA repair through its nicking activity on methylated DNA. Binds with similar affinity to both methylated and non-methylated DNA. Highly distributive behavior on DNA substrates containing multiple 5-meC residues. Involved with Pol IV in the remodeling of the 5S rDNA chromatin via DNA methylation modifications during the first days of development post-germination. Participates in UV-B induced- and oxidative DNA damage repair (PubMed:24155752). |
| UniProt Protein Details: | |
| NCBI Summary: | A repressor of transcriptional gene silencing. Functions by demethylating the target promoter DNA. Interacts physically with RPA2/ROR1. In the ros1 mutants, an increase in methylation is observed in a number of gene promoters. Among the loci affected by ros1, a few (RD29A and At1g76930) are affected in cytosine methylation in all sequence contexts (CpG, CpNpG or CpNpN), although many others are affected primarily in non-CpG contexts. |
| UniProt Code: | Q9SJQ6 |
| NCBI GenInfo Identifier: | 42569673 |
| NCBI Gene ID: | 818224 |
| NCBI Accession: | NP_181190.3 |
| UniProt Secondary Accession: | Q9SJQ6,Q7Y1X6 |
| UniProt Related Accession: | Q9SJQ6 |
| Molecular Weight: | |
| NCBI Full Name: | demeter-like 1 |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | DML1 |
| NCBI Official Synonym Symbols: | AtROS1; demeter-like 1; F1O11.12; F1O11_12; REPRESSOR OF SILENCING1; ROS1 |
| NCBI Protein Information: | demeter-like 1 |
| UniProt Protein Name: | Protein ROS1 |
| UniProt Synonym Protein Names: | DEMETER-like protein 1; Repressor of silencing 1 |
| Protein Family: | Protein |
| UniProt Gene Name: | ROS1 |
| UniProt Entry Name: | ROS1_ARATH |
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