ROGDI Antibody (PACO40770)
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주문- SKU:
- PACO40770
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ROGDI Antibody (PACO40770) |
Antibody SKU: | PACO40770 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Protein rogdi homolog protein (14-287AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: ROGDI antibody at 1.2µg/ml. Lane 1: Hela whole cell lysate. Lane 2: K562 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 33 kDa. Observed band size: 33 kDa. |
![]() | Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO40770 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO40770 at dilution of 1:100. |
Background: | May act as a positive regulator of cell proliferation. |
Synonyms: | Protein rogdi homolog, ROGDI |
UniProt Protein Function: | ROGDI: May act as a positive regulator of cell proliferation. Defects in ROGDI are the cause of Kohlschuetter-Toenz syndrome (KTZS). An autosomal recessive disorder characterized by severe global developmental delay, early-onset intractable seizures, spasticity, and amelogenesis imperfecta affecting both primary and secondary teeth and causing yellow or brown discoloration of the teeth. Although the phenotype is consistent, there is variability. Intellectual disability is related to the severity of seizures, and the disorder can thus be considered an epileptic encephalopathy. Some infants show normal development until seizure onset, whereas others are delayed from birth. The most severely affected individuals have profound mental retardation, never acquire speech, and become bedridden early in life. Belongs to the rogdi family.Protein type: Cell cycle regulationChromosomal Location of Human Ortholog: 16p13.3Cellular Component: nuclear envelope; intracellularBiological Process: positive regulation of cell proliferation; hemopoiesisDisease: Kohlschutter-tonz Syndrome |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a protein of unknown function. Loss-of-function mutation in this gene cause Kohlschutter-Tonz syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012] |
UniProt Code: | Q9GZN7 |
NCBI GenInfo Identifier: | 13375779 |
NCBI Gene ID: | 79641 |
NCBI Accession: | NP_078865.1 |
UniProt Secondary Accession: | Q9GZN7,Q6IA00 |
UniProt Related Accession: | Q9GZN7 |
Molecular Weight: | 32,254 Da |
NCBI Full Name: | protein rogdi homolog |
NCBI Synonym Full Names: | rogdi homolog (Drosophila) |
NCBI Official Symbol: | ROGDI |
NCBI Official Synonym Symbols: | KTZS |
NCBI Protein Information: | protein rogdi homolog; leucine zipper domain protein |
UniProt Protein Name: | Protein rogdi homolog |
UniProt Synonym Protein Names: | |
Protein Family: | Protein rogdi |
UniProt Gene Name: | ROGDI |
UniProt Entry Name: | ROGDI_HUMAN |