RNF212 Antibody (PACO11873)
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주문- SKU:
- PACO11873
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | RNF212 Antibody (PACO11873) |
Antibody SKU: | PACO11873 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Human RNF212 |
Form: | Liquid |
Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | ring finger protein 212;RNF212;FLJ38841;MGC120227;MGC120228;ZHP3 ; |
UniProt Protein Function: | RNF212: SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination. 6 human isoforms produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 6.3.2.-; Ubiquitin conjugating system; SUMO ligase; Ligase Chromosomal Location of Human Ortholog: 4p16.3 Cellular Component: synaptonemal complex Molecular Function:zinc ion binding; ligase activity Biological Process: protein sumoylation; meiotic recombination; meiotic gene conversion; chiasma formation Disease: Recombination Rate Quantitative Trait Locus 1 |
NCBI Summary: | This gene encodes a RING finger protein that may function as a ubiquitin ligase. The encoded protein may be involved in meiotic recombination. This gene is located within a linkage disequilibrium block and polymorphisms in this gene may influence recombination rates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010] |
UniProt Code: | Q495C1 |
NCBI GenInfo Identifier: | 121943260 |
NCBI Gene ID: | 285498 |
NCBI Accession: | Q495C1.1 |
UniProt Secondary Accession: | Q495C1,Q495C0, Q86W82, Q8IY99, Q8N8U7, C9J8N0, |
UniProt Related Accession: | Q495C1 |
Molecular Weight: | 297 |
NCBI Full Name: | Probable E3 SUMO-protein ligase RNF212 |
NCBI Synonym Full Names: | ring finger protein 212 |
NCBI Official Symbol: | RNF212 |
NCBI Official Synonym Symbols: | ZHP3 |
NCBI Protein Information: | probable E3 SUMO-protein ligase RNF212 |
UniProt Protein Name: | Probable E3 SUMO-protein ligase RNF212 |
UniProt Synonym Protein Names: | RING finger protein 212 |
Protein Family: | Probable E3 SUMO-protein ligase |
UniProt Gene Name: | RNF212 |
UniProt Entry Name: | RN212_HUMAN |