RIC8A Antibody (PACO45621)
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주문- SKU:
- PACO45621
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | RIC8A Antibody (PACO45621) |
Antibody SKU: | PACO45621 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Synembryn-A protein (362-531AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO45621 at dilution of 1:100. |
Background: | Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-α proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-α protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-α (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. |
Synonyms: | Synembryn-A (Protein Ric-8A), RIC8A |
UniProt Protein Function: | RIC8A: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. Belongs to the synembryn family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:GEFs; GEFs, misc. Chromosomal Location of Human Ortholog: 11p15.5 Cellular Component: cytoplasm; plasma membrane Molecular Function:G-protein alpha-subunit binding; GTPase activator activity; guanyl-nucleotide exchange factor activity; protein binding Biological Process: G-protein coupled receptor protein signaling pathway |
UniProt Code: | Q9NPQ8 |
NCBI GenInfo Identifier: | 308153562 |
NCBI Gene ID: | 60626 |
NCBI Accession: | Q9NPQ8.3 |
UniProt Secondary Accession: | Q9NPQ8,Q0P508, Q2T9J1, Q7Z352, Q96EZ1, Q96SZ2, Q9H064 Q9H5H3, Q9H9E7, |
UniProt Related Accession: | Q9NPQ8 |
Molecular Weight: | 59,612 Da |
NCBI Full Name: | Synembryn-A |
NCBI Synonym Full Names: | RIC8 guanine nucleotide exchange factor A |
NCBI Official Symbol: | RIC8A |
NCBI Official Synonym Symbols: | RIC8 |
NCBI Protein Information: | synembryn-A |
UniProt Protein Name: | Synembryn-A |
UniProt Synonym Protein Names: | Protein Ric-8A |
Protein Family: | Synembryn |
UniProt Gene Name: | RIC8A |
UniProt Entry Name: | RIC8A_HUMAN |