RHOD Antibody (PACO56956)
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주문- SKU:
- PACO56956
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | RHOD Antibody (PACO56956) |
Antibody SKU: | PACO56956 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Rho-related GTP-binding protein RhoD protein (1-80AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunofluorescence staining of MCF-7 cells with PACO56956 at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution. |
Synonyms: | Rho-related GTP-binding protein RhoD (Rho-related protein HP1) (RhoHP1), RHOD, ARHD |
UniProt Protein Function: | RHOD: Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Participates in reorganization of actin cytoskeleton. Belongs to the small GTPase superfamily. Rho family. |
UniProt Protein Details: | Protein type:G protein; G protein, monomeric, Rho; G protein, monomeric; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11q14.3 Cellular Component: early endosome; plasma membrane; cytosol Molecular Function:GTPase activity; GTP binding; protein kinase binding Biological Process: focal adhesion formation; lamellipodium biogenesis; actin filament bundle formation; regulation of small GTPase mediated signal transduction; positive regulation of cell adhesion; metabolic process; small GTPase mediated signal transduction; regulation of focal adhesion formation; Rho protein signal transduction; protein targeting; positive regulation of cell migration |
NCBI Summary: | Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] |
UniProt Code: | O00212 |
NCBI GenInfo Identifier: | 254763327 |
NCBI Gene ID: | 29984 |
NCBI Accession: | O00212.2 |
UniProt Related Accession: | O00212 |
Molecular Weight: | 210 |
NCBI Full Name: | Rho-related GTP-binding protein RhoD |
NCBI Synonym Full Names: | ras homolog family member D |
NCBI Official Symbol: | RHOD |
NCBI Official Synonym Symbols: | Rho; ARHD; RHOM; RHOHP1 |
NCBI Protein Information: | rho-related GTP-binding protein RhoD; ras homolog D; Rho-related protein HP1; ras homolog gene family, member A; ras homolog gene family, member D |
UniProt Protein Name: | Rho-related GTP-binding protein RhoD |
UniProt Synonym Protein Names: | Rho-related protein HP1; RhoHP1 |
Protein Family: | Rhodopsin |
UniProt Gene Name: | RHOD |
UniProt Entry Name: | RHOD_HUMAN |