RDH5 Antibody (PACO44524)
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주문- SKU:
- PACO44524
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | RDH5 Antibody (PACO44524) |
Antibody SKU: | PACO44524 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human 11-cis retinol dehydrogenase protein (24-318AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO44524 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human colon tissue using PACO44524 at dilution of 1:100. |
Background: | Stereospecific 11-cis retinol dehydrogenase, which catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments. Also able to oxidize 9-cis-retinol and 13-cis-retinol, but not all-trans-retinol. Active in the presence of NAD as cofactor but not in the presence of NADP. |
Synonyms: | 11-cis retinol dehydrogenase (11-cis RDH) (11-cis RoDH) (EC 1.1.1.315) (9-cis retinol dehydrogenase) (9cRDH) (Retinol dehydrogenase 5) (Short chain dehydrogenase/reductase family 9C member 5), RDH5, HSD17B9 RDH1 SDR9C5 |
UniProt Protein Function: | RDH5: Stereospecific 11-cis retinol dehydrogenase, which catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments. Also able to oxidize 9-cis-retinol and 13-cis-retinol, but not all- trans-retinol. Active in the presence of NAD as cofactor but not in the presence of NADP. Defects in RDH5 are a cause of retinitis punctata albescens (RPA); also known as fundus albipunctatus (FA). RPA is a rare form of stationary night blindness characterized by a delay in the regeneration of cone and rod photopigments. Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
UniProt Protein Details: | Protein type:Cofactor and Vitamin Metabolism - retinol; Endoplasmic reticulum; Oxidoreductase; EC 1.1.1.315 Chromosomal Location of Human Ortholog: 12q13-q14 Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum lumen Molecular Function:retinol dehydrogenase activity Biological Process: phototransduction, visible light; visual perception; retinol metabolic process; retinoid metabolic process Disease: Fundus Albipunctatus |
NCBI Summary: | This gene encodes an enzyme belonging to the short-chain dehydrogenases/reductases (SDR) family. This retinol dehydrogenase functions to catalyze the final step in the biosynthesis of 11-cis retinaldehyde, which is the universal chromophore of visual pigments. Mutations in this gene cause autosomal recessive fundus albipunctatus, a rare form of night blindness that is characterized by a delay in the regeneration of cone and rod photopigments. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S1 (biogenesis of lysosomal organelles complex-1, subunit 1) gene. [provided by RefSeq, Dec 2010] |
UniProt Code: | Q92781 |
NCBI GenInfo Identifier: | 2492753 |
NCBI Gene ID: | 5959 |
NCBI Accession: | Q92781.1 |
UniProt Secondary Accession: | Q92781,O00179, Q8TAI2, |
UniProt Related Accession: | Q92781 |
Molecular Weight: | 34,979 Da |
NCBI Full Name: | 11-cis retinol dehydrogenase |
NCBI Synonym Full Names: | retinol dehydrogenase 5 (11-cis/9-cis) |
NCBI Official Symbol: | RDH5 |
NCBI Official Synonym Symbols: | RDH1; 9cRDH; SDR9C5; HSD17B9 |
NCBI Protein Information: | 11-cis retinol dehydrogenase; 11-cis RDH; 11-cis RoDH; retinol dehydrogenase 1; 9-cis retinol dehydrogenase; 9-cis-retinol specific dehydrogenase; retinol dehydrogenase 5 (11-cis and 9-cis); short chain dehydrogenase/reductase family 9C, member 5 |
UniProt Protein Name: | 11-cis retinol dehydrogenase |
UniProt Synonym Protein Names: | 9-cis retinol dehydrogenase; 9cRDH |
Protein Family: | 11-cis retinol dehydrogenase |
UniProt Gene Name: | RDH5 |
UniProt Entry Name: | RDH1_HUMAN |
Antibodies |
Anti-RDH5 Antibody (CAB8055) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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