RBPMS Antibody (PACO31856)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO31856
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | RBPMS Antibody (PACO31856) |
Antibody SKU: | PACO31856 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human RNA-binding protein with multiple splicing protein (1-219AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO31856 at dilution of 1:100. |
![]() | Immunofluorescent analysis of PC-3 cells using PACO31856 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA. |
Synonyms: | RNA-binding protein with multiple splicing (RBP-MS) (Heart and RRM expressed sequence) (Hermes), RBPMS, HERMES |
UniProt Protein Function: | RBPMS: Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C- terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 8p12 Cellular Component: nucleoplasm; cytoplasm Molecular Function:protein binding; transcription coactivator activity; nucleotide binding; poly(A) binding Biological Process: RNA processing; regulation of transcription, DNA-dependent; transcription, DNA-dependent |
NCBI Summary: | This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013] |
UniProt Code: | Q93062 |
NCBI GenInfo Identifier: | 13124469 |
NCBI Gene ID: | 11030 |
NCBI Accession: | Q93062.1 |
UniProt Related Accession: | Q93062 |
Molecular Weight: | Observed Molecular Weight: (Observed)21kD.Predicted Molecular Weight: (Calculated)22kDa. |
NCBI Full Name: | RNA-binding protein with multiple splicing |
NCBI Synonym Full Names: | RNA binding protein, mRNA processing factor |
NCBI Official Symbol: | RBPMS |
NCBI Official Synonym Symbols: | HERMES |
NCBI Protein Information: | RNA-binding protein with multiple splicing |
UniProt Protein Name: | RNA-binding protein with multiple splicing |
UniProt Synonym Protein Names: | Heart and RRM expressed sequence; Hermes |
Protein Family: | RNA-binding protein with multiple splicing |
UniProt Gene Name: | RBPMS |
UniProt Entry Name: | RBPMS_HUMAN |