Rat GHBP Recombinant Protein (RPPB0352)

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SKU:
RPPB0352
Product type:
Recombinant Protein
Size:
10ug
Species:
Rat
Target:
GHBP
Synonyms:
GHBP
Synonyms:
 GH receptor
Source:
Sf9 Insect cells
Uniprot:
P16310
€0.00
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Description

Product Name:Rat GHBP Recombinant Protein
Product Code:RPPB0352
Size:10µg
Species:Rat
Target:GHBP
Synonyms:GHBP, GH receptor.
Source:Sf9 Insect cells
Physical Appearance:Sterilefiltered colorless solution.
Formulation:GHBP protein solution (0.5mg/ml) contains phosphate buffered saline (pH7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:FPGSGATPAT LGKASPVLQR INPSLRESSS GKPRFTKCRS PELETFSCYWTEGDDHNLKV PGSIQLYYAR RIAHEWTPEW KECPDYVSAG ANSCYFNSSY TSIWIPYCIK LTTNGDLLKEKCFTVDEIVQ PDPPIGLNWT LLNISLPGIR GDIQVSWQPP PSADVLKGWI ILEYEIQYKEVNETKWKTMS PIWSTSVPLY SLRLDKEHEV RVRSRQRSFE KYSEFSEVLRVTFPQMDTLA ACEEDFRLEH HHHHH

GH receptor, also known as GHR is part of the cytokine receptor family. GHR binds 2 receptor molecules and in this manner induces signal transduction through receptor dimerization. Furthermore, at high concentrations, GH performs as an antagonist since there is a large difference in affinities at the respective binding sites. The antagonist action can be enhanced further by reducing binding in the low affinity binding site.

GHBP produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 255 amino acids (19-265.a.) and having a molecular mass of 29.4kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).GHBP is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:GH receptor: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. Defects in GHR are a cause of Laron syndrome (LARS). A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may be a cause of idiopathic short stature autosomal (ISSA). Short stature is defined by a subnormal rate of growth. Belongs to the type I cytokine receptor family. Type 1 subfamily. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Receptor, cytokineCellular Component: cell soma; cell surface; cytoplasm; extracellular space; extrinsic to membrane; integral to membrane; integral to plasma membrane; mitochondrion; nucleus; plasma membrane; receptor complexMolecular Function: growth factor binding; growth hormone receptor activity; peptide hormone binding; protein homodimerization activity; protein kinase binding; protein phosphatase binding; SH2 domain bindingBiological Process: 2-oxoglutarate metabolic process; activation of JAK protein; activation of MAPK activity; allantoin metabolic process; cellular response to hormone stimulus; cellular response to insulin stimulus; citrate metabolic process; creatine metabolic process; creatinine metabolic process; fatty acid metabolic process; hormone-mediated signaling; insulin-like growth factor receptor signaling pathway; isoleucine metabolic process; JAK-STAT cascade; multicellular organismal metabolic process; oxaloacetate metabolic process; positive regulation of cell differentiation; positive regulation of JAK-STAT cascade; positive regulation of multicellular organism growth; positive regulation of peptidyl-tyrosine phosphorylation; receptor internalization; regulation of multicellular organism growth; response to cycloheximide; response to cytokine stimulus; response to estradiol stimulus; response to food; response to glucocorticoid stimulus; response to hormone stimulus; response to morphine; response to peptide hormone stimulus; succinate metabolic process; taurine metabolic process; tyrosine phosphorylation of JAK2 protein; valine metabolic process
UniProt Protein Details:
NCBI Summary:
UniProt Code:P16310
NCBI GenInfo Identifier:8393434
NCBI Gene ID:25235
NCBI Accession:NP_058790.1
UniProt Secondary Accession:P16310,Q64236, Q80XW9
UniProt Related Accession:P16310
Molecular Weight:31,957 Da
NCBI Full Name:growth hormone receptor
NCBI Synonym Full Names:growth hormone receptor
NCBI Official Symbol:Ghr  
NCBI Official Synonym Symbols:GHR/BP  
NCBI Protein Information:growth hormone receptor
UniProt Protein Name:Growth hormone receptor
UniProt Synonym Protein Names:Somatotropin receptor
Protein Family:Growth hormone receptor
UniProt Gene Name:Ghr  
UniProt Entry Name:GHR_RAT
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