RAB31 Antibody (PACO44676)
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주문- SKU:
- PACO44676
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | RAB31 Antibody (PACO44676) |
Antibody SKU: | PACO44676 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Ras-related protein Rab-31 protein (1-194AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human testis tissue using PACO44676 at dilution of 1:100. |
Background: | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. |
Synonyms: | Ras-related protein Rab-31 (Ras-related protein Rab-22B), RAB31, RAB22B |
UniProt Protein Function: | RAB31: Belongs to the small GTPase superfamily. Rab family |
UniProt Protein Details: | Protein type:G protein, monomeric; G protein; G protein, monomeric, Rab Chromosomal Location of Human Ortholog: 18p11.3 Cellular Component: phagocytic vesicle membrane; late endosome; early endosome; trans-Golgi network membrane; phagocytic vesicle Molecular Function:GTPase activity; GDP binding; GTP binding Biological Process: regulated secretory pathway; cellular response to insulin stimulus; receptor internalization; Golgi to plasma membrane protein transport; Rab protein signal transduction |
NCBI Summary: | Small GTP-binding proteins of the RAB family, such as RAB31, play essential roles in vesicle and granule targeting (Bao et al., 2002 [PubMed 11784320]).[supplied by OMIM, Jul 2009] |
UniProt Code: | Q13636 |
NCBI GenInfo Identifier: | 2500069 |
NCBI Gene ID: | 11031 |
NCBI Accession: | Q13636.1 |
UniProt Secondary Accession: | Q13636,Q15770, Q9HC00, B2RBT7, |
UniProt Related Accession: | Q13636 |
Molecular Weight: | 194 |
NCBI Full Name: | Ras-related protein Rab-31 |
NCBI Synonym Full Names: | RAB31, member RAS oncogene family |
NCBI Official Symbol: | RAB31 |
NCBI Official Synonym Symbols: | Rab22B |
NCBI Protein Information: | ras-related protein Rab-31; ras-related protein Rab-22B |
UniProt Protein Name: | Ras-related protein Rab-31 |
UniProt Synonym Protein Names: | Ras-related protein Rab-22B |
Protein Family: | Ras-related protein |
UniProt Gene Name: | RAB31 |
UniProt Entry Name: | RAB31_HUMAN |
Antibodies |
Anti-RAB31 Antibody (CAB3667) |
Anti-RAB31 Antibody (CAB7506) |
RAB31 Antibody (PACO02387) |
RAB31 Antibody (PACO11647) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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