PYCR1 Antibody (PACO29284)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO29284
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PYCR1 Antibody (PACO29284) |
Antibody SKU: | PACO29284 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Pyrroline-5-carboxylate reductase 1, mitochondrial protein (2-319AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human breast cancer using PACO29284 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human colon cancer using PACO29284 at dilution of 1:100. |
Background: | Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress. |
Synonyms: | Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2), PYCR1 |
UniProt Protein Function: | PYCR1: Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress. Defects in PYCR1 are the cause of cutis laxa autosomal recessive type 2B (ARCL2B). A multisystem disorder characterized by the appearance of premature aging, wrinkled and lax skin with reduced elasticity, joint laxity, craniofacial dysmorphic features, intrauterine growth retardation with some degree of postnatal growth deficiency, and developmental delay. Defects in PYCR1 are the cause of cutis laxa, autosomal recessive, type 3B (ARCL3B). ARCL3B is a disorder characterized by an aged appearance with distinctive facial features, sparse hair, ophthalmologic abnormalities, intrauterine growth retardation, and cutis laxa. Belongs to the pyrroline-5-carboxylate reductase family. |
UniProt Protein Details: | Protein type:EC 1.5.1.2; Oxidoreductase; Mitochondrial; Amino Acid Metabolism - arginine and proline Chromosomal Location of Human Ortholog: 17q25.3 Cellular Component: mitochondrial matrix; mitochondrion Molecular Function:identical protein binding; protein binding; pyrroline-5-carboxylate reductase activity Biological Process: amino acid biosynthetic process; proline biosynthetic process; regulation of mitochondrial membrane potential Disease: Cutis Laxa, Autosomal Recessive, Type Iib; Cutis Laxa, Autosomal Recessive, Type Iiib |
NCBI Summary: | This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
UniProt Code: | P32322 |
NCBI GenInfo Identifier: | 60416434 |
NCBI Gene ID: | 5831 |
NCBI Accession: | P32322.2 |
UniProt Secondary Accession: | P32322,Q6FHI4, Q96DI6, Q9HBQ4, A6NFM2, B4DMU0, |
UniProt Related Accession: | P32322 |
Molecular Weight: | 35,981 Da |
NCBI Full Name: | Pyrroline-5-carboxylate reductase 1, mitochondrial |
NCBI Synonym Full Names: | pyrroline-5-carboxylate reductase 1 |
NCBI Official Symbol: | PYCR1 |
NCBI Official Synonym Symbols: | P5C; P5CR; PRO3; PYCR; PIG45; PP222; ARCL2B; ARCL3B |
NCBI Protein Information: | pyrroline-5-carboxylate reductase 1, mitochondrial |
UniProt Protein Name: | Pyrroline-5-carboxylate reductase 1, mitochondrial |
Protein Family: | Pyrroline-5-carboxylate reductase |
UniProt Gene Name: | PYCR1 |
UniProt Entry Name: | P5CR1_HUMAN |