Purified Anti-Mouse CD274/PD-L1 Antibody [10F.9G2] (AGEL1637)

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SKU:
AGEL1637
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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Purified Anti-Mouse CD274/PD-L1 Antibody [10F.9G2]

The Purified Mouse CD274 (PD-L1) Monoclonal Antibody (10F.9G2) from Assay Genie is a highly specific antibody designed for research involving the PD-L1 protein. PD-L1, also known as programmed death-ligand 1, is a critical immune checkpoint molecule that plays a key role in regulating the immune response and maintaining immune tolerance.This monoclonal antibody, generated against mouse PD-L1, is ideal for detecting and analyzing PD-L1 expression in various research applications, such as flow cytometry, immunohistochemistry, and western blotting.

Its high specificity and sensitivity make it a valuable tool for studying the role of PD-L1 in immune evasion, cancer progression, and autoimmune diseases.By targeting PD-L1, researchers can gain insights into the complex interactions between cancer cells and the immune system, paving the way for innovative immunotherapy strategies. This antibody is a valuable asset for any laboratory conducting research in the fields of immunology, oncology, and autoimmunity.

Product Title:Purified Anti-Mouse CD274/PD-L1 Antibody [10F.9G2]
SKU:AGEL1637
Size:25µg, 100µg
Clone No:10F.9G2
Synonyms:B7-H1; PD-L1;Programmed cell death ligand 1;B7 homolog 1;B7-H; B7H1; PDL1; PDCD1L1; PDCD1LG1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:Purified Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:Q9EP73
Gene ID:60533
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

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