PTPRE Antibody (PACO44174)
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주문- SKU:
- PACO44174
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PTPRE Antibody (PACO44174) |
Antibody SKU: | PACO44174 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Receptor-type tyrosine-protein phosphatase epsilon protein (20-200AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: PTPRE antibody at 0.6 µg/ml. Lane 1: Mouse kidney tissue. Lane 2: Mouse brain tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 81, 75, 72 kDa. Observed band size: 81 kDa.. |
![]() | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO44174 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human testis tissue using PACO44174 at dilution of 1:100. |
Background: | Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). |
Synonyms: | Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48), PTPRE |
UniProt Protein Function: | PTPRE: a cytoplasmic and transmembrane receptor protein tyrosine phosphatase that regulates IL-10 and TNFA biosynthesis, myelination and cell-matrix adhesion, overexpression reduces tumor development |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral; EC 3.1.3.48; Receptor protein phosphatase, tyrosine Chromosomal Location of Human Ortholog: 10q26 Cellular Component: cytoplasm; nucleus; plasma membrane Molecular Function:protein binding; transmembrane receptor protein tyrosine phosphatase activity Biological Process: negative regulation of insulin receptor signaling pathway; protein amino acid dephosphorylation |
NCBI Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Oct 2015] |
UniProt Code: | P23469 |
NCBI GenInfo Identifier: | 126471 |
NCBI Gene ID: | 5791 |
NCBI Accession: | P23469.1 |
UniProt Secondary Accession: | P23469,Q13345, Q5VWH3, Q5VWH4, Q96KQ6, |
UniProt Related Accession: | P23469 |
Molecular Weight: | 71,382 Da |
NCBI Full Name: | Receptor-type tyrosine-protein phosphatase epsilon |
NCBI Synonym Full Names: | protein tyrosine phosphatase, receptor type E |
NCBI Official Symbol: | PTPRE |
NCBI Official Synonym Symbols: | PTPE; HPTPE; R-PTP-EPSILON |
NCBI Protein Information: | receptor-type tyrosine-protein phosphatase epsilon |
UniProt Protein Name: | Receptor-type tyrosine-protein phosphatase epsilon |
Protein Family: | Receptor-type tyrosine-protein phosphatase |
UniProt Gene Name: | PTPRE |
UniProt Entry Name: | PTPRE_HUMAN |