PTPN7 Antibody (PACO16907)
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주문- SKU:
- PACO16907
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PTPN7 Antibody (PACO16907) |
Antibody SKU: | PACO16907 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human PTPN7 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 231 cells, Primary antibody: PACO16907(PTPN7 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. | |
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16907(PTPN7 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. |
Synonyms: | protein tyrosine phosphatase, non-receptor type 7 |
UniProt Protein Function: | Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction. |
NCBI Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010] |
UniProt Code: | P35236 |
NCBI GenInfo Identifier: | 20141721 |
NCBI Gene ID: | 5778 |
NCBI Accession: | P35236.3 |
UniProt Secondary Accession: | P35236,Q53XK4, Q5SXQ0, Q5SXQ1, Q9BV05, B3KXE1, |
UniProt Related Accession: | P35236 |
Molecular Weight: | 52,284 Da |
NCBI Full Name: | Tyrosine-protein phosphatase non-receptor type 7 |
NCBI Synonym Full Names: | protein tyrosine phosphatase, non-receptor type 7 |
NCBI Official Symbol: | PTPN7 |
NCBI Official Synonym Symbols: | LPTP; HEPTP; PTPNI; BPTP-4; LC-PTP |
NCBI Protein Information: | tyrosine-protein phosphatase non-receptor type 7 |
UniProt Protein Name: | Tyrosine-protein phosphatase non-receptor type 7 |
UniProt Synonym Protein Names: | Hematopoietic protein-tyrosine phosphatase; HEPTP; Protein-tyrosine phosphatase LC-PTP |
Protein Family: | Tyrosine-protein phosphatase non-receptor |
UniProt Gene Name: | PTPN7 |
UniProt Entry Name: | PTN7_HUMAN |