PTHLH Antibody (PACO14946)
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주문- SKU:
- PACO14946
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | PTHLH Antibody (PACO14946) |
Antibody SKU: | PACO14946 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human PTHLH |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14946(PTHLH Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO14946(PTHLH Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The protein encoded by this gene is a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, in-frame and downstream of the initiator AUG codon, to give rise to nuclear forms of this hormone. |
Synonyms: | parathyroid hormone-like hormone |
UniProt Protein Function: | PTHrP: a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Three alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 12p12.1-p11.2 Cellular Component: nucleoplasm; Golgi apparatus; extracellular space; cytoplasm; extracellular region Molecular Function:peptide hormone receptor binding; hormone activity Biological Process: epidermis development; negative regulation of transcription factor activity; negative regulation of chondrocyte differentiation; female pregnancy; G-protein signaling, adenylate cyclase activating pathway; osteoblast development; negative regulation of cell proliferation; cAMP metabolic process; epithelial cell differentiation; cell-cell signaling; regulation of gene expression; positive regulation of cell proliferation; positive regulation of cAMP biosynthetic process; protein processing; skeletal development; surfactant homeostasis; alveolus development; endochondral ossification; endoderm development Disease: Brachydactyly, Type E2 |
NCBI Summary: | The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone. [provided by RefSeq, Nov 2013] |
UniProt Code: | P12272 |
NCBI GenInfo Identifier: | 131542 |
NCBI Gene ID: | 5744 |
NCBI Accession: | P12272.1 |
UniProt Secondary Accession: | P12272,Q15251, Q6FH74, |
UniProt Related Accession: | P12272 |
Molecular Weight: | Calculated MW: 19kDa/20kDa/23kDa |
NCBI Full Name: | Parathyroid hormone-related protein |
NCBI Synonym Full Names: | parathyroid hormone-like hormone |
NCBI Official Symbol: | PTHLH |
NCBI Official Synonym Symbols: | HHM; PLP; BDE2; PTHR; PTHRP |
NCBI Protein Information: | parathyroid hormone-related protein; PTH-rP; osteostatin; PTH-related protein; parathyroid hormone-like related protein; parathyroid hormone-like hormone preproprotein |
UniProt Protein Name: | Parathyroid hormone-related protein |
UniProt Synonym Protein Names: | Parathyroid hormone-like protein; PLP |
Protein Family: | Parathyroid hormone-related protein |
UniProt Gene Name: | PTHLH |
UniProt Entry Name: | PTHR_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |