PTGES3 Antibody (PACO15149)
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주문- SKU:
- PACO15149
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PTGES3 Antibody (PACO15149) |
Antibody SKU: | PACO15149 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human PTGES3 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15149(PTGES3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | Prostaglandin E synthase 3 (cytosolic) is an enzyme that in humans is encoded by the PTGES3 gene. The protein encoded by this gene is also known as p23 which functions as a chaperone which is required for proper functioning of the glucocorticoid and other steroid receptors. Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. |
Synonyms: | prostaglandin E synthase 3 (cytosolic) |
UniProt Protein Function: | TEBP: Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Belongs to the p23/wos2 family. |
UniProt Protein Details: | Protein type:Transferase; Chaperone; Nuclear receptor co-regulator; EC 5.3.99.3; Isomerase Chromosomal Location of Human Ortholog: 12q13.3|12 Cellular Component: chromosome, telomeric region; cytoplasm; cytosol; nucleoplasm; nucleus; telomerase holoenzyme complex Molecular Function:prostaglandin-E synthase activity; protein binding; telomerase activity; unfolded protein binding Biological Process: arachidonic acid metabolic process; cyclooxygenase pathway; prostaglandin biosynthetic process; RNA-dependent DNA replication; signal transduction; telomere maintenance |
NCBI Summary: | This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes. [provided by RefSeq, Feb 2016] |
UniProt Code: | Q15185 |
NCBI GenInfo Identifier: | 8928247 |
NCBI Gene ID: | 10728 |
NCBI Accession: | Q15185.1 |
UniProt Secondary Accession: | Q15185,Q8WU70, A8K7D0, B4DHP2, B4DP11, B4DP21, |
UniProt Related Accession: | Q15185 |
Molecular Weight: | 16,476 Da |
NCBI Full Name: | Prostaglandin E synthase 3 |
NCBI Synonym Full Names: | prostaglandin E synthase 3 |
NCBI Official Symbol: | PTGES3 |
NCBI Official Synonym Symbols: | P23; TEBP; cPGES |
NCBI Protein Information: | prostaglandin E synthase 3 |
UniProt Protein Name: | Prostaglandin E synthase 3 |
UniProt Synonym Protein Names: | Cytosolic prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23 |
UniProt Gene Name: | PTGES3 |
UniProt Entry Name: | TEBP_HUMAN |
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