PSMD7 Antibody (PACO14931)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO14931
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | PSMD7 Antibody (PACO14931) |
Antibody SKU: | PACO14931 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human PSMD7 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO14931(PSMD7 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO14931(PSMD7 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 α subunits and 2 rings are composed of 7 β subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17. |
Synonyms: | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 |
UniProt Protein Function: | PSMD7: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Belongs to the peptidase M67A family. |
UniProt Protein Details: | Protein type:Proteasome complex; Protease Chromosomal Location of Human Ortholog: 16q22.3 Cellular Component: proteasome complex; nucleoplasm; membrane; proteasome regulatory particle; nucleus; cytosol Molecular Function:protein binding; protein homodimerization activity Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; negative regulation of apoptosis; G1/S transition of mitotic cell cycle |
NCBI Summary: | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2008] |
UniProt Code: | P51665 |
NCBI GenInfo Identifier: | 20532412 |
NCBI Gene ID: | 5713 |
NCBI Accession: | P51665.2 |
UniProt Secondary Accession: | P51665,Q6PKI2, Q96E97, D3DWS9, |
UniProt Related Accession: | P51665 |
Molecular Weight: | 324 |
NCBI Full Name: | 26S proteasome non-ATPase regulatory subunit 7 |
NCBI Synonym Full Names: | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 |
NCBI Official Symbol: | PSMD7 |
NCBI Official Synonym Symbols: | P40; S12; Rpn8; MOV34 |
NCBI Protein Information: | 26S proteasome non-ATPase regulatory subunit 7; Mov34 homolog; proteasome subunit p40; 26S proteasome regulatory subunit S12; 26S proteasome regulatory subunit rpn8; Moloney leukemia virus-34 proviral integration; proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog) |
UniProt Protein Name: | 26S proteasome non-ATPase regulatory subunit 7 |
UniProt Synonym Protein Names: | 26S proteasome regulatory subunit RPN8; 26S proteasome regulatory subunit S12; Mov34 protein homolog; Proteasome subunit p40 |
Protein Family: | 26S proteasome non-ATPase regulatory |
UniProt Gene Name: | PSMD7 |
UniProt Entry Name: | PSMD7_HUMAN |