PRPF4 Antibody (PACO45614)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO45614
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PRPF4 Antibody (PACO45614) |
Antibody SKU: | PACO45614 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human U4/U6 small nuclear ribonucleoprotein Prp4 protein (1-260AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: PRPF4 antibody at 3.89 µg/ml. Lane 1: Jurkat whole cell lysate. Lane 2: Hela whole cell lysate. Lane 3: HepG2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 58 kDa. Observed band size: 58 kDa.. | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO45614 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO45614 at dilution of 1:100. |
Background: | Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. |
Synonyms: | U4/U6 small nuclear ribonucleoprotein Prp4 (PRP4 homolog) (hPrp4) (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4), PRPF4, PRP4 |
UniProt Protein Function: | PRPF4: Involved in pre-mRNA splicing. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Spliceosome; RNA processing; RNA splicing Chromosomal Location of Human Ortholog: 9q31-q33 Cellular Component: nucleoplasm; Cajal body; spliceosome; U4/U6 x U5 tri-snRNP complex; nuclear speck; nucleus Molecular Function:U4 snRNA binding; protein binding; U6 snRNA binding Biological Process: RNA processing; nuclear mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; RNA splicing; gene expression Disease: Retinitis Pigmentosa 70 |
NCBI Summary: | The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of chemoresistance in human ovarian cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
UniProt Code: | O43172 |
NCBI GenInfo Identifier: | 20514971 |
NCBI Gene ID: | 9128 |
NCBI Accession: | O43172.2 |
UniProt Secondary Accession: | O43172,O43445, O43864, Q5T1M8, Q96DG2, Q96IK4, |
UniProt Related Accession: | O43172 |
Molecular Weight: | 522 |
NCBI Full Name: | U4/U6 small nuclear ribonucleoprotein Prp4 |
NCBI Synonym Full Names: | pre-mRNA processing factor 4 |
NCBI Official Symbol: | PRPF4 |
NCBI Official Synonym Symbols: | PRP4; RP70; HPRP4; Prp4p; HPRP4P; SNRNP60 |
NCBI Protein Information: | U4/U6 small nuclear ribonucleoprotein Prp4; PRP4 homolog; WD splicing factor Prp4; U4/U6 snRNP 60 kDa protein; PRP4/STK/WD splicing factor; PRP4 pre-mRNA processing factor 4 homolog |
UniProt Protein Name: | U4/U6 small nuclear ribonucleoprotein Prp4 |
UniProt Synonym Protein Names: | PRP4 homolog; hPrp4; U4/U6 snRNP 60 kDa protein; WD splicing factor Prp4 |
UniProt Gene Name: | PRPF4 |
UniProt Entry Name: | PRP4_HUMAN |