PROKR2 Antibody (PACO53718)
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주문- SKU:
- PACO53718
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PROKR2 Antibody (PACO53718) |
Antibody SKU: | PACO53718 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Prokineticin receptor 2 protein (1-45AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human endometrial cancer using PACO53718 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human colon cancer using PACO53718 at dilution of 1:100. |
Background: | Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. |
Synonyms: | Prokineticin receptor 2 (PK-R2) (G-protein coupled receptor 73-like 1) (G-protein coupled receptor I5E) (GPR73b) (GPRg2), PROKR2, GPR73L1 PKR2 |
UniProt Protein Function: | PROKR2: Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. Defects in PROKR2 are the cause of Kallmann syndrome type 3 (KAL3); also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin- releasing hormone-synthesizing neurons. KAL3 patients have variable degrees of olfactory and reproductive dysfunction, but do not show any of the occasional clinical anomalies reported in Kallmann syndrome such as renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. Belongs to the G-protein coupled receptor 1 family. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1 Chromosomal Location of Human Ortholog: 20p12.3 Cellular Component: integral to membrane; plasma membrane Molecular Function:neuropeptide Y receptor activity Biological Process: circadian rhythm; neuropeptide signaling pathway Disease: Hypogonadotropic Hypogonadism 3 With Or Without Anosmia |
NCBI Summary: | Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8NFJ6 |
NCBI GenInfo Identifier: | 33112425 |
NCBI Gene ID: | 128674 |
NCBI Accession: | Q8NFJ6.1 |
UniProt Secondary Accession: | Q8NFJ6,Q2M3C0, Q5TDY1, Q9NTT0, A5JUU1, |
UniProt Related Accession: | Q8NFJ6 |
Molecular Weight: | 384 |
NCBI Full Name: | Prokineticin receptor 2 |
NCBI Synonym Full Names: | prokineticin receptor 2 |
NCBI Official Symbol: | PROKR2 |
NCBI Official Synonym Symbols: | HH3; KAL3; PKR2; GPRg2; GPR73b; GPR73L1; dJ680N4.3 |
NCBI Protein Information: | prokineticin receptor 2; PK-R2; G protein-coupled receptor 73-like 1 |
UniProt Protein Name: | Prokineticin receptor 2 |
UniProt Synonym Protein Names: | G-protein coupled receptor 73-like 1; GPR73b; GPRg2 |
Protein Family: | Prokineticin receptor |
UniProt Gene Name: | PROKR2 |
UniProt Entry Name: | PKR2_HUMAN |
Antibodies | ELISA Kits |
Anti-PROKR2 Antibody (CAB2960) | Human PKR2 (Prokineticin Receptor 2) CLIA Kit (HUES01015) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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